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首页> Journal of pharmaceutical and biomedical analysis> Simultaneous determination of donepezil, 6-O-desmethyl donepezil and spinosin in beagle dog plasma using liquid chromatography‒tandem mass spectrometry and its application to a drug-drug interaction study.

Simultaneous determination of donepezil, 6-O-desmethyl donepezil and spinosin in beagle dog plasma using liquid chromatography‒tandem mass spectrometry and its application to a drug-drug interaction study.

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作者： Chae Bin,Lee ^[1] ; Jee Sun,Min ^[1] ; Soon Uk,Chae ^[1] ; Hye Min,Kim ^[2] ; Jun Hee,Jang ^[2] ; In Ho,Jung ^[3] ; Yu Fen,Zheng ^[4] ; Jong Hoon,Ryu ^[5] ; Soo Kyung,Bae ^[6]

作者单位： College of Pharmacy and Integrated Research Institute of Pharmaceutical Sciences, The Catholic University of Korea, Bucheon 14662, Republic of Korea. ^[1] Daehwa Pharmaceutical Co., Ltd., Seongnam 13488, Republic of Korea. ^[2] Daehwa Pharmaceutical Co., Ltd., Seongnam 13488, Republic of Korea; Department of Life and Nanopharmaceutical Sciences, Kyung Hee University, Seoul 02447, Republic of Korea. ^[3] Department of Clinical Pharmacy, China Pharmaceutical University, Nanjing, 210000, China. ^[4] Department of Life and Nanopharmaceutical Sciences, Kyung Hee University, Seoul 02447, Republic of Korea. ^[5] College of Pharmacy and Integrated Research Institute of Pharmaceutical Sciences, The Catholic University of Korea, Bucheon 14662, Republic of Korea. Electronic address: baesk@catholic.ac.kr. ^[6]

关键词 6-O-desmethyl donepezil Beagle dog plasma Donepezil Drug-drug interaction LC?MS/MS Spinosin

主题词动物(Animals);色谱法, 高压液相(Chromatography, High Pressure Liquid);狗(Dogs);药物相互作用(Drug Interactions);类黄酮物质(Flavonoids);茚满类(Indans);男(雄)性(Male);哌啶类(Piperidines);血浆(Plasma);结果可重复性(Reproducibility of Results);韩国(Republic of Korea);种子(Seeds);串联质谱法(Tandem Mass Spectrometry);枣属(Ziziphus)

DOI 10.1016/j.jpba.2019.112919

PMID 31654856

发布时间 2020-06-04

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Journal of pharmaceutical and biomedical analysis

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