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首页> American journal of physiology. Endocrinology and metabolism> Cardiac overexpression of perilipin 2 induces atrial steatosis, connexin 43 remodeling, and atrial fibrillation in aged mice.

Cardiac overexpression of perilipin 2 induces atrial steatosis, connexin 43 remodeling, and atrial fibrillation in aged mice.

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作者： Satsuki,Sato ^[1] ; Jinya,Suzuki ^[1] ; Masamichi,Hirose ^[2] ; Mika,Yamada ^[1] ; Yasuo,Zenimaru ^[1] ; Takahiro,Nakaya ^[1] ; Mai,Ichikawa ^[1] ; Michiko,Imagawa ^[1] ; Sadao,Takahashi ^[3] ; Shoichiro,Ikuyama ^[4] ; Tadashi,Konoshita ^[5] ; Fredric B,Kraemer ^[1] ; Tamotsu,Ishizuka ^[6]

作者单位： Third Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui, Fukui, Japan. ^[1] Department of Molecular and Cellular Pharmacology, Iwate Medical University School of Pharmaceutical Sciences, Iwate, Japan. ^[2] Division of Diabetes Medicine, Ageo Central General Hospital, Saitama, Japan. ^[3] Laboratory of Clinical Nutrition and Medicine, Kagawa Nutrition University, Tokyo, Japan. ^[4] Division of Endocrinology and Metabolism, Oita San-ai Medical Center, Oita, Japan. ^[5] Veterans Affairs Palo Alto Health Care System, Palo Alto, California. ^[6] Division of Endocrinology, Stanford University, Stanford, California. ^[7]

关键词 aging cardiac steatosis gap junction lipid droplets lipotoxic arrhythmia

主题词动物(Animals);心房颤动(Atrial Fibrillation);连接蛋白43(Connexin 43);基因敲入技术(Gene Knock-In Techniques);心房(Heart Atria);小鼠(Mice);小鼠, 转基因(Mice, Transgenic);显微镜检查, 电子(Microscopy, Electron);肌细胞, 心脏(Myocytes, Cardiac);固醇酯酶(Sterol Esterase);甘油三酯类(Triglycerides);电压敏感染色成像(Voltage-Sensitive Dye Imaging)

DOI 10.1152/ajpendo.00227.2019

PMID 31661297

发布时间 2020-12-01

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American journal of physiology. Endocrinology and metabolism

American journal of physiology. Endocrinology and metabolism

2019年317卷6期

E1193-E1204页

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American journal of physiology. Endocrinology and metabolism

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American journal of physiology. Endocrinology and metabolism

2019年317卷6期

E1193-E1204页

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