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首页> Bioorganic chemistry> Design and synthesis of tetrahydropyridopyrimidine derivatives as dual GPR119 and DPP-4 modulators.

Design and synthesis of tetrahydropyridopyrimidine derivatives as dual GPR119 and DPP-4 modulators.

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作者： Yuanying,Fang ^[1] ; Shaokun,Zhang ^[2] ; Wenting,Wu ^[3] ; Yanhua,Liu ^[3] ; Juan,Yang ^[2] ; Yuyuan,Li ^[3] ; Min,Li ^[3] ; Huanhuan,Dong ^[3] ; Yi,Jin ^[4] ; Ronghua,Liu ^[3] ; Zunhua,Yang ^[5]

作者单位： College of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China; National Engineering Research Center for Manufacturing Technology of TCM Solid Preparation, Jiangxi University of Traditional Chinese Medicine, Nanchang 330006, China. ^[1] National Engineering Research Center for Manufacturing Technology of TCM Solid Preparation, Jiangxi University of Traditional Chinese Medicine, Nanchang 330006, China. ^[2] College of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China. ^[3] National Engineering Research Center for Manufacturing Technology of TCM Solid Preparation, Jiangxi University of Traditional Chinese Medicine, Nanchang 330006, China. Electronic address: yinghua616909@hotmail.com. ^[4] College of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China. Electronic address: joshyyy@126.com. ^[5]

关键词 DPP-4 Design GPR119 Hypoglycemic activity Tetrahydropyridopyrimidine

主题词动物(Animals);血糖(Blood Glucose);CHO细胞(CHO Cells);仓鼠属(Cricetulus);二肽基肽酶4(Dipeptidyl Peptidase 4);二肽基肽酶Ⅳ抑制剂(Dipeptidyl-Peptidase IV Inhibitors);剂量效应关系, 药物(Dose-Response Relationship, Drug);药物设计(Drug Design);葡糖耐量试验(Glucose Tolerance Test);人类(Humans);降血糖药(Hypoglycemic Agents);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);分子结构(Molecular Structure);嘧啶类(Pyrimidines);吡咯烷类(Pyrrolidines);受体, G-蛋白偶联(Receptors, G-Protein-Coupled);构效关系(Structure-Activity Relationship)

DOI 10.1016/j.bioorg.2019.103390

PMID 31662212

发布时间 2021-02-17

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Bioorganic chemistry

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