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The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity.

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第一作者： Jude,Canon

第一单位： Amgen Research, Amgen Inc, Thousand Oaks, CA, USA. jcanon@amgen.com.

作者： Jude,Canon ^[1] ; Karen,Rex ^[2] ; Anne Y,Saiki ^[2] ; Christopher,Mohr ^[2] ; Keegan,Cooke ^[2] ; Dhanashri,Bagal ^[3] ; Kevin,Gaida ^[2] ; Tyler,Holt ^[2] ; Charles G,Knutson ^[4] ; Neelima,Koppada ^[4] ; Brian A,Lanman ^[2] ; Jonathan,Werner ^[2] ; Aaron S,Rapaport ^[3] ; Tisha,San Miguel ^[2] ; Roberto,Ortiz ^[5] ; Tao,Osgood ^[2] ; Ji-Rong,Sun ^[2] ; Xiaochun,Zhu ^[6] ; John D,McCarter ^[2] ; Laurie P,Volak ^[7] ; Brett E,Houk ^[8] ; Marwan G,Fakih ^[9] ; Bert H,O'Neil ^[10] ; Timothy J,Price ^[11] ; Gerald S,Falchook ^[12] ; Jayesh,Desai ^[13] ; James,Kuo ^[14] ; Ramaswamy,Govindan ^[15] ; David S,Hong ^[16] ; Wenjun,Ouyang ^[3] ; Haby,Henary ^[8] ; Tara,Arvedson ^[3] ; Victor J,Cee ^[2] ; J Russell,Lipford ^[17]

作者单位： Amgen Research, Amgen Inc, Thousand Oaks, CA, USA. jcanon@amgen.com. ^[1] Amgen Research, Amgen Inc, Thousand Oaks, CA, USA. ^[2] Amgen Research, Amgen Inc, South San Francisco, CA, USA. ^[3] Amgen Research, Amgen Inc, Cambridge, MA, USA. ^[4] Amgen Research, Amgen Inc, Cambridge, MA, USA.;Pfizer, La Jolla, CA, USA. ^[5] Amgen Research, Amgen Inc, Cambridge, MA, USA.;Takeda, Cambridge, MA, USA. ^[6] Amgen Research, Amgen Inc, Cambridge, MA, USA.;Celgene, San Diego, CA, USA. ^[7] Amgen Clinical Development, Amgen Inc, Thousand Oaks, CA, USA. ^[8] City of Hope, Duarte, CA, USA. ^[9] Indiana University School of Medicine, Indianapolis, IN, USA. ^[10] The Queen Elizabeth Hospital, Woodville, South Australia, Australia.;University of Adelaide, Adelaide, South Australia, Australia. ^[11] Sarah Cannon Research Institute, Denver, CO, USA. ^[12] Peter MacCallum Cancer Center, Melbourne, Victoria, Australia. ^[13] Scientia Clinical Research, Randwick, New South Wales, Australia. ^[14] Washington University School of Medicine, St Louis, MO, USA. ^[15] The University of Texas MD Anderson Cancer Center, Houston, TX, USA. ^[16] Amgen Research, Amgen Inc, Thousand Oaks, CA, USA. jlipford@amgen.com. ^[17]