Mesenchymal stem cells cultured under hypoxic conditions had a greater therapeutic effect on mice with liver cirrhosis compared to those cultured under normal oxygen conditions.
第一作者:
Yuichi,Kojima
第一单位:
Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, 1-757 Asahimachi-dori, Chuo-ku, Niigata, 951-8510, Japan.
作者:
关键词
8-OHdG, DNA 8-hydroxy-2’-deoxyguanosineALB, AlbuminALP, Alkaline phosphataseALT, Alanine aminotransferaseCAGE, Cap analysis of gene expressionCCl4, Carbon tetrachlorideECM, Extracellular matrixHHSteC, Human Hepatic Stellate CellsHypoxic conditionLC, Liver cirrhosisLPS, LipopolysaccharideLiver cirrhosisMDA, MalondialdehydeMSCs, Mesenchymal stem cellsMesenchymal stem cellsNASH, Non-alcoholic steatohepatitisPCR, Polymerase chain reactionPGE2PGE2, Prostaglandin E2SOD, Superoxide dismutaseT-Bil, Total bilirubinhypoMSCs, MSCs cultured under hypoxic oxygen (5 O2) conditionsid-BMM, Induced Bone Marrow Derived MacrophagemiR210norMSCs, MSCs cultured under normal oxygen (21 O2) conditions
DOI
10.1016/j.reth.2019.08.005
PMID
31667206
发布时间
2022-04-11
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Regenerative therapy
2019年11卷
269-281页
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