Acetaldehyde dehydrogenase 2 deficiency exacerbates cardiac fibrosis by promoting mobilization and homing of bone marrow fibroblast progenitor cells.

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作者： Xiao,Li ^[1] ; Xinyu,Weng ^[1] ; Huairui,Shi ^[2] ; Rifeng,Gao ^[3] ; Peng,Wang ^[2] ; Daile,Jia ^[2] ; Shuqi,Zhang ^[2] ; Zhen,Dong ^[2] ; Xiaolei,Sun ^[2] ; Jie,Yang ^[2] ; Zeng,Wang ^[1] ; Rongle,Liu ^[1] ; Yufan,Li ^[2] ; Zhiwei,Qiu ^[2] ; Kai,Hu ^[2] ; Aijun,Sun ^[4] ; Junbo,Ge ^[5]

作者单位： Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China; Department of Cardiology, Zhongshan Hospital, Fudan University. Shanghai Institute of Cardiovascular Diseases, Shanghai 200032, China. ^[1] Department of Cardiology, Zhongshan Hospital, Fudan University. Shanghai Institute of Cardiovascular Diseases, Shanghai 200032, China. ^[2] Department of Cardiovascular Surgery, The Second Affiliated Hospital of Nanchang University, China. ^[3] Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China; Department of Cardiology, Zhongshan Hospital, Fudan University. Shanghai Institute of Cardiovascular Diseases, Shanghai 200032, China. Electronic address: sun.aijun@zs-hospital.sh.cn. ^[4] Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China; Department of Cardiology, Zhongshan Hospital, Fudan University. Shanghai Institute of Cardiovascular Diseases, Shanghai 200032, China. Electronic address: jbge@zs-hospital.sh.cn. ^[5]

关键词 ALDH2 Cardiac fibrosis FPCs ROS SDF-1

主题词动物(Animals);动物, 新生(Animals, Newborn);骨髓细胞(Bone Marrow Cells);细胞极性(Cell Polarity);细胞增殖(Cell Proliferation);趋化因子CXCL12(Chemokine CXCL12);缩窄, 病理性(Constriction, Pathologic);成纤维细胞(Fibroblasts);纤维化(Fibrosis);男(雄)性(Male);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 基因敲除(Mice, Knockout);模型, 生物学(Models, Biological);心肌(Myocardium);氧化性应激(Oxidative Stress);受体, CXCR4(Receptors, CXCR4);信号传导(Signal Transduction);干细胞(Stem Cells)

DOI 10.1016/j.yjmcc.2019.10.006

PMID 31668970

发布时间 2020-07-09

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Journal of molecular and cellular cardiology

2019年137卷

107-118页

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Acetaldehyde dehydrogenase 2 deficiency exacerbates cardiac fibrosis by promoting mobilization and homing of bone marrow fibroblast progenitor cells.

Journal of molecular and cellular cardiology

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Journal of molecular and cellular cardiology

相关期刊

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Acetaldehyde dehydrogenase 2 deficiency exacerbates cardiac fibrosis by promoting mobilization and homing of bone marrow fibroblast progenitor cells.

Journal of molecular and cellular cardiology

相似文献

Journal of molecular and cellular cardiology

相关期刊

检索历史清除