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Design and synthesis of biaryloxazolidinone derivatives containing amide or acrylamide moiety as novel antibacterial agents against Gram-positive bacteria.

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第一作者： Sicong,Xu

第一单位： Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University), Ministry of Education, 103 Wenhua Road, Shenhe District, Shenyang 110016, China.

作者： Sicong,Xu ^[1] ; Jia,Jiang ^[1] ; Yinliang,Qi ^[1] ; Xiudong,Ding ^[2] ; Yachuang,Wu ^[1] ; Hong,Lei ^[3] ; Yanfang,Zhao ^[4]

作者单位： Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University), Ministry of Education, 103 Wenhua Road, Shenhe District, Shenyang 110016, China. ^[1] Department of Clinical Laboratory, The 309th Hospital of Chinese People's Liberation Army, Beijing 100091, China. ^[2] Department of Clinical Laboratory, The 309th Hospital of Chinese People's Liberation Army, Beijing 100091, China. Electronic address: jlh309@163.com. ^[3] Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University), Ministry of Education, 103 Wenhua Road, Shenhe District, Shenyang 110016, China. Electronic address: yanfangzhao@126.com. ^[4]

关键词 Antibacterial activity Biaryloxazolidinone Gram-positive bacteria

医学主题词丙烯酰胺(Acrylamide);酰胺类(Amides);抗菌药(Anti-Bacterial Agents);革兰氏阳性菌(Gram-Positive Bacteria);人类(Humans);分子结构(Molecular Structure);构效关系(Structure-Activity Relationship)

DOI 10.1016/j.bmcl.2019.126747

PMID 31668973

发布时间 2020-09-24

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准确一般字义偏差语意偏离译文作用小提交