Cerebrospinal fluid neurogranin in an inducible mouse model of neurodegeneration: A translatable marker of synaptic degeneration.

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第一作者： Kina,Höglund

第一单位： Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden; Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Disease Research, Neurogeriatrics Division, Karolinska Institutet, Novum, Huddinge, Stockholm, Sweden.

作者： Kina,Höglund ^[1] ; Nathalie,Schussler ^[2] ; Hlin,Kvartsberg ^[3] ; Una,Smailovic ^[4] ; Gunnar,Brinkmalm ^[5] ; Victor,Liman ^[6] ; Bruno,Becker ^[5] ; Henrik,Zetterberg ^[7] ; Angel,Cedazo-Minguez ^[8] ; Shorena,Janelidze ^[9] ; Isabel A,Lefevre ^[8] ; Stéphanie,Eyquem ^[8] ; Oskar,Hansson ^[10] ; Kaj,Blennow ^[5]

作者单位： Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden; Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Disease Research, Neurogeriatrics Division, Karolinska Institutet, Novum, Huddinge, Stockholm, Sweden. ^[1] Sanofi R&D, Rare & Neurologic Diseases Research Therapeutic Area, Neurodegeneration Research, 1 Avenue Pierre Brossolette, Chilly Mazarin 91380, France. Electronic address: nathalie.schussler@sanofi.com. ^[2] Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden. ^[3] Department of Neurobiology, Care Sciences and Society, Division of Clinical Geriatrics, Karolinska Institutet, Huddinge, Stockholm, Sweden. ^[4] Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden. ^[5] Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden. ^[6] Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden; Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, UK; UK Dementia Research Institute at UCL, London, UK. ^[7] Sanofi R&D, Rare & Neurologic Diseases Research Therapeutic Area, Neurodegeneration Research, 1 Avenue Pierre Brossolette, Chilly Mazarin 91380, France. ^[8] Clinical Memory Research Unit, Lund University, Sweden. ^[9] Clinical Memory Research Unit, Lund University, Sweden; Memory Clinic, Skåne University Hospital, Skåne, Sweden. ^[10]

关键词 Alzheimer's disease CSF biomarker Inducible p25 mice Neurogranin SIMOA Synaptic loss