DJ-1 can form β-sheet structured aggregates that co-localize with pathological amyloid deposits.

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第一作者： Katalin,Solti

第一单位： TTK-NAP B - Drug Discovery Research Group - Neurodegenerative Diseases, Institute of Organic Chemistry, Research Center for Natural Sciences, Budapest, Hungary.

作者： Katalin,Solti ^[1] ; Wei-Li,Kuan ^[2] ; Balázs,Fórizs ^[3] ; Gergely,Kustos ^[4] ; Judith,Mihály ^[5] ; Zoltán,Varga ^[5] ; Balázs,Herberth ^[3] ; Éva,Moravcsik ^[4] ; Róbert,Kiss ^[1] ; Manuela,Kárpáti ^[4] ; Anna,Mikes ^[1] ; Yanyan,Zhao ^[6] ; Tímea,Imre ^[7] ; Jean-Christophe,Rochet ^[8] ; Franklin,Aigbirhio ^[6] ; Caroline H,Williams-Gray ^[2] ; Roger A,Barker ^[2] ; Gergely,Tóth ^[9]

作者单位： TTK-NAP B - Drug Discovery Research Group - Neurodegenerative Diseases, Institute of Organic Chemistry, Research Center for Natural Sciences, Budapest, Hungary. ^[1] John van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Forvie Site, Robinson Way, Cambridge CB2 0PY, UK. ^[2] TTK-NAP B - Drug Discovery Research Group - Neurodegenerative Diseases, Institute of Organic Chemistry, Research Center for Natural Sciences, Budapest, Hungary; Cantabio Pharmaceuticals, Palo Alto, CA, USA. ^[3] Cantabio Pharmaceuticals, Palo Alto, CA, USA. ^[4] Institute of Materials and Environmental Chemistry Research Centre for Natural Sciences, Budapest, Hungary. ^[5] Molecular Imaging Chemistry Laboratory, Wolfson Brain Imaging Centre, Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0QQ, UK. ^[6] MS Metabolomic Research Laboratory, Institute of Organic Chemistry, Research Center for Natural Sciences, Budapest, Hungary. ^[7] Department of Medicinal Chemistry and Molecular Pharmacology and Purdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, Indiana, USA. ^[8] TTK-NAP B - Drug Discovery Research Group - Neurodegenerative Diseases, Institute of Organic Chemistry, Research Center for Natural Sciences, Budapest, Hungary; Cantabio Pharmaceuticals, Palo Alto, CA, USA. Electronic address: toth.gergely@ttk.hu. ^[9]

关键词 Aggregation Alzheimer's Amyloid DJ-1 Parkinson's

主题词阿尔茨海默病(Alzheimer Disease);脑(Brain);人类(Humans);Lewy体(Lewy Bodies);神经原纤维缠结(Neurofibrillary Tangles);帕金森病(Parkinson Disease);斑块, 淀粉样(Plaque, Amyloid)

DOI 10.1016/j.nbd.2019.104629

PMID 31669752

发布时间 2021-03-17

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Neurobiology of disease

2020年134卷

104629页

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DJ-1 can form β-sheet structured aggregates that co-localize with pathological amyloid deposits.

Neurobiology of disease

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Neurobiology of disease

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DJ-1 can form β-sheet structured aggregates that co-localize with pathological amyloid deposits.

Neurobiology of disease

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Neurobiology of disease

相关期刊

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