Population pharmacokinetics of vactosertib, a new TGF-β receptor type Ι inhibitor, in patients with advanced solid tumors.

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第一作者： Su Young,Jung

第一单位： Department of Pharmacy, College of Pharmacy, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, Republic of Korea.;Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, Republic of Korea.

作者： Su Young,Jung ^[1] ; Ji Seob,Yug ^[2] ; Jeffery M,Clarke ^[3] ; Todd M,Bauer ^[4] ; Vicki L,Keedy ^[5] ; Sunjin,Hwang ^[6] ; Seong-Jin,Kim ^[6] ; Eun Kyoung,Chung ^[7] ; Jangik I,Lee ^[8]

作者单位： Department of Pharmacy, College of Pharmacy, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, Republic of Korea.;Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, Republic of Korea. ^[1] Department of Pharmacy, College of Pharmacy, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul, 02447, Republic of Korea. ^[2] Duke University Medical Center, Durham, NC, USA. ^[3] Sarah Cannon Research Institute/Tennessee Oncology PLLC, Nashville, TN, USA. ^[4] Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA. ^[5] MedPacto, Inc, Seoul, Republic of Korea. ^[6] Department of Pharmacy, College of Pharmacy, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul, 02447, Republic of Korea. cekchung@khu.ac.kr. ^[7] Department of Pharmacy, College of Pharmacy, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, Republic of Korea. jangik.lee@snu.ac.kr.;Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, Republic of Korea. jangik.lee@snu.ac.kr. ^[8]

关键词 Phase 1 Population pharmacokinetics Solid tumors TGF-β signaling inhibitor Vactosertib