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首页> eLife> High-throughput, single-particle tracking reveals nested membrane domains that dictate KRas<sup>G12D</sup> diffusion and trafficking.

High-throughput, single-particle tracking reveals nested membrane domains that dictate KRas<sup>G12D</sup> diffusion and trafficking.

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作者： Yerim,Lee ^[1] ; Carey,Phelps ^[2] ; Tao,Huang ^[1] ; Barmak,Mostofian ^[2] ; Lei,Wu ^[1] ; Ying,Zhang ^[2] ; Kai,Tao ^[1] ; Young Hwan,Chang ^[2] ; Philip Js,Stork ^[1] ; Joe W,Gray ^[2] ; Daniel M,Zuckerman ^[3] ; Xiaolin,Nan ^[1]

作者单位： Department of Biomedical Engineering, Oregon Health and Science University, Portland, United States. ^[1] OHSU Center for Spatial Systems Biomedicine (OCSSB), Oregon Health and Science University, Portland, United States. ^[2] Department of Oral Maxillofacial-Head Neck Oncology, School and Hospital of Stomatology, Wuhan University, Wuhan, China. ^[3] Vollum Institute, Oregon Health and Science University, Portland, United States. ^[4] Knight Cancer Early Detection Advanced Research (CEDAR) Center, Oregon Health and Science University, Portland, United States. ^[5]

关键词 Ras diffusion endocytosis membrane nanodomain molecular biophysics non-equilibrium steady state none physics of living systems single-particle tracking structural biology

主题词细胞系, 肿瘤(Cell Line, Tumor);细胞膜(Cell Membrane);细胞运动(Cell Movement);扩散(Diffusion);高通量筛选分析(High-Throughput Screening Assays);人类(Humans);动力学(Kinetics);发光蛋白质类(Luminescent Proteins);膜微区(Membrane Microdomains);模型, 生物学(Models, Biological);突变, 误义(Mutation, Missense);蛋白质转运(Protein Transport);原癌基因蛋白质类p21(ras)(Proto-Oncogene Proteins p21(ras));信号传导(Signal Transduction)

DOI 10.7554/eLife.46393

PMID 31674905

发布时间 2020-12-22

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