首页> eLife> Retro-2 protects cells from ricin toxicity by inhibiting ASNA1-mediated ER targeting and insertion of tail-anchored proteins.

Retro-2 protects cells from ricin toxicity by inhibiting ASNA1-mediated ER targeting and insertion of tail-anchored proteins.

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第一作者： David W,Morgens

第一单位： Department of Genetics, Stanford University, Stanford, United States.

作者： David W,Morgens ^[1] ; Charlene,Chan ^[2] ; Andrew J,Kane ^[2] ; Nicholas R,Weir ^[2] ; Amy,Li ^[1] ; Michael M,Dubreuil ^[3] ; C Kimberly,Tsui ^[1] ; Gaelen T,Hess ^[1] ; Adam,Lavertu ^[4] ; Kyuho,Han ^[1] ; Nicole,Polyakov ^[2] ; Jing,Zhou ^[2] ; Emma L,Handy ^[5] ; Philip,Alabi ^[5] ; Amanda,Dombroski ^[5] ; David,Yao ^[1] ; Russ B,Altman ^[6] ; Jason K,Sello ^[5] ; Vladimir,Denic ^[2] ; Michael C,Bassik ^[7]

作者单位： Department of Genetics, Stanford University, Stanford, United States. ^[1] Department of Molecular and Cellular Biology, Northwest Labs, Harvard University, Cambridge, United States. ^[2] Program in Cancer Biology, Stanford University, Stanford, United States. ^[3] Biomedical Informatics Training Program, Stanford University, Stanford, United States. ^[4] Department of Chemistry, Brown University, Providence, United States. ^[5] Department of Genetics, Stanford University, Stanford, United States.;Bioengineering, Stanford University, Stanford, United States. ^[6] Department of Genetics, Stanford University, Stanford, United States.;Program in Cancer Biology, Stanford University, Stanford, United States.;Stanford University Chemistry, Engineering, and Medicine for Human Health (ChEM-H), Stanford, United States. ^[7]

关键词 CRISPR Retro-2 TRC pathway cell biology genetics genomics human