Zika NS2B is a crucial factor recruiting NS3 to the ER and activating its protease activity.

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作者： Huaipeng,Xing ^[1] ; Shan,Xu ^[1] ; Fangfei,Jia ^[1] ; Yang,Yang ^[1] ; Caimin,Xu ^[1] ; Chengfeng,Qin ^[2] ; Lei,Shi ^[3]

作者单位： State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, Beijing, 100005, China; Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, Beijing, 100005, China. ^[1] State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, 100005, China. Electronic address: qincf@bmi.ac.cn. ^[2] State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, Beijing, 100005, China; Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, Beijing, 100005, China. Electronic address: shilei@ibms.pumc.edu.cn. ^[3]

关键词 NS2B NS3 protease Recruitment Zika virus

主题词内质网(Endoplasmic Reticulum);HEK293细胞(HEK293 Cells);人类(Humans);线粒体(Mitochondria);突变(Mutation);肽水解酶类(Peptide Hydrolases);蛋白质结合(Protein Binding);丝氨酸内肽酶类(Serine Endopeptidases);病毒非结构蛋白质类(Viral Nonstructural Proteins);病毒蛋白质类(Viral Proteins);病毒复制(Virus Replication)

DOI 10.1016/j.virusres.2019.197793

PMID 31676367

发布时间 2021-02-05

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Virus research

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Zika NS2B is a crucial factor recruiting NS3 to the ER and activating its protease activity.

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Zika NS2B is a crucial factor recruiting NS3 to the ER and activating its protease activity.

Virus research

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Virus research

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