Farnesol abrogates epithelial to mesenchymal transition process through regulating Akt/mTOR pathway.

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作者： Jong Hyun,Lee ^[1] ; Arunachalam,Chinnathambi ^[2] ; Sulaiman Ali,Alharbi ^[2] ; Omar H M,Shair ^[2] ; Gautam,Sethi ^[3] ; Kwang Seok,Ahn ^[4]

作者单位： Department of Science in Korean Medicine, Kyung Hee University, 24 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea. ^[1] Department of Botany and Microbiology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia. ^[2] Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117600, Singapore. Electronic address: phcgs@nus.edu.sg. ^[3] Department of Science in Korean Medicine, Kyung Hee University, 24 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea. Electronic address: ksahn@khu.ac.kr. ^[4]

关键词 Akt EMT Farnesol NSCLC TGF-β

主题词动物(Animals);抗肿瘤药(Antineoplastic Agents);癌, 非小细胞肺(Carcinoma, Non-Small-Cell Lung);细胞系(Cell Line);细胞运动(Cell Movement);细胞增殖(Cell Proliferation);上皮-间质转化(Epithelial-Mesenchymal Transition);法尼醇(Farnesol);女(雌)性(Female);人类(Humans);肺肿瘤(Lung Neoplasms);小鼠, 裸(Mice, Nude);原癌基因蛋白质c-akt(Proto-Oncogene Proteins c-akt);信号传导(Signal Transduction);TOR丝氨酸-苏氨酸激酶(TOR Serine-Threonine Kinases);伤口愈合(Wound Healing)

DOI 10.1016/j.phrs.2019.104504

PMID 31678208

发布时间 2021-12-04

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Pharmacological research

2019年150卷

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Farnesol abrogates epithelial to mesenchymal transition process through regulating Akt/mTOR pathway.

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Farnesol abrogates epithelial to mesenchymal transition process through regulating Akt/mTOR pathway.

Pharmacological research

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Pharmacological research

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