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Resistance to autosomal dominant Alzheimer's disease in an APOE3 Christchurch homozygote: a case report.

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第一作者: Joseph F,Arboleda-Velasquez
第一单位: Schepens Eye Research Institute of Mass Eye and Ear and Department of Ophthalmology, Harvard Medical School, Boston, MA, USA. joseph_arboleda@meei.harvard.edu.
作者单位: Schepens Eye Research Institute of Mass Eye and Ear and Department of Ophthalmology, Harvard Medical School, Boston, MA, USA. joseph_arboleda@meei.harvard.edu. [1] Grupo de Neurociencias de Antioquia de la Universidad de Antioquia, Medellin, Colombia. [2] Schepens Eye Research Institute of Mass Eye and Ear and Department of Ophthalmology, Harvard Medical School, Boston, MA, USA. [3] Schepens Eye Research Institute of Mass Eye and Ear and Department of Ophthalmology, Harvard Medical School, Boston, MA, USA.;Boston College, Boston, MA, USA. [4] Massachusetts General Hospital and Department of Neurology, Harvard Medical School, Boston, MA, USA. [5] Massachusetts General Hospital and Department of Neurology, Harvard Medical School, Boston, MA, USA.;Brigham and Women's Hospital and the Department of Neurology, Harvard Medical School, Boston, MA, USA. [6] Schepens Eye Research Institute of Mass Eye and Ear and Department of Ophthalmology, Harvard Medical School, Boston, MA, USA.;Universidad Escuela de Ingenieria de Antioquia-EIA, Medellin, Colombia. [7] The Banner Alzheimer's Institute, Phoenix, AZ, USA.;University of Arizona, Tucson, AZ, USA.;Arizona State University, Tempe, AZ, USA. [8] Massachusetts General Hospital and the Department of Psychiatry, Harvard Medical School, Boston, MA, USA. [9] Massachusetts General Hospital and the Department of Psychiatry, Harvard Medical School, Boston, MA, USA.;Department of Psychology, Gordon College, Wenham, MA, USA. [10] Grupo de Neurociencias de Antioquia de la Universidad de Antioquia, Medellin, Colombia.;Neuroscience Research Institute, Department of Molecular Cellular Developmental Biology, University of California, Santa Barbara, Santa Barbara, CA, USA. [11] Neuroscience Research Institute, Department of Molecular Cellular Developmental Biology, University of California, Santa Barbara, Santa Barbara, CA, USA. [12] Neurogenomics Division, The Translational Genomics Research Institute, Phoenix, AZ, USA. [13] Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.;Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden.;Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK.;UK Dementia Research Institute at UCL, London, UK. [14] Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.;Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden. [15] The Banner Alzheimer's Institute, Phoenix, AZ, USA. [16] Department of Medicine, Boston University School of Medicine, Boston, MA, USA. [17] Center for Personalized Medicine, Department of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, CA, USA.;Department of Pathology, Keck School of Medicine of University of Southern California, Los Angeles, CA, USA. [18] Center for Personalized Medicine, Department of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, CA, USA. [19] Mass Eye and Ear and Department of Ophthalmology, Harvard Medical School, Boston, MA, USA. [20] The Banner Alzheimer's Institute, Phoenix, AZ, USA.;University of Arizona, Tucson, AZ, USA. [21] Massachusetts General Hospital and Department of Neurology, Harvard Medical School, Boston, MA, USA.;Brigham and Women's Hospital and the Department of Neurology, Harvard Medical School, Boston, MA, USA.;Massachusetts General Hospital and Department of Radiology, Harvard Medical School, Boston, MA, USA. [22] The Banner Alzheimer's Institute, Phoenix, AZ, USA. eric.reiman@bannerhealth.com.;University of Arizona, Tucson, AZ, USA. eric.reiman@bannerhealth.com.;Arizona State University, Tempe, AZ, USA. eric.reiman@bannerhealth.com.;Neurogenomics Division, The Translational Genomics Research Institute, Phoenix, AZ, USA. eric.reiman@bannerhealth.com. [23] Grupo de Neurociencias de Antioquia de la Universidad de Antioquia, Medellin, Colombia. yquiroz@mgh.harvard.edu.;Massachusetts General Hospital and Department of Neurology, Harvard Medical School, Boston, MA, USA. yquiroz@mgh.harvard.edu.;Massachusetts General Hospital and the Department of Psychiatry, Harvard Medical School, Boston, MA, USA. yquiroz@mgh.harvard.edu. [24]
DOI 10.1038/s41591-019-0611-3
PMID 31686034
发布时间 2024-08-28
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