Extension of the Notch intracellular domain ankyrin repeat stack by NRARP promotes feedback inhibition of Notch signaling.
第一作者:
Sanchez M,Jarrett
第一单位:
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.
作者:
主题词
人类(Humans);细胞内信号肽和蛋白质类(Intracellular Signaling Peptides and Proteins);Jurkat细胞(Jurkat Cells);多蛋白复合物(Multiprotein Complexes);突变(Mutation);肿瘤蛋白质类(Neoplasm Proteins);前体T细胞淋巴母细胞白血病淋巴瘤(Precursor T-Cell Lymphoblastic Leukemia-Lymphoma);蛋白质结构, 四级(Protein Structure, Quaternary);受体, Notch(Receptors, Notch);信号传导(Signal Transduction)
DOI
10.1126/scisignal.aay2369
PMID
31690634
发布时间
2020-08-21
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