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Efficacy and Safety of Dupilumab in Adolescents With Uncontrolled Moderate to Severe Atopic Dermatitis: A Phase 3 Randomized Clinical Trial.

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第一作者： Eric L,Simpson

第一单位： Department of Dermatology, Oregon Health & Science University, Portland.

作者： Eric L,Simpson ^[1] ; Amy S,Paller ^[2] ; Elaine C,Siegfried ^[3] ; Mark,Boguniewicz ^[4] ; Lawrence,Sher ^[5] ; Melinda J,Gooderham ^[6] ; Lisa A,Beck ^[7] ; Emma,Guttman-Yassky ^[8] ; David,Pariser ^[9] ; Andrew,Blauvelt ^[10] ; Jamie,Weisman ^[11] ; Benjamin,Lockshin ^[12] ; Thomas,Hultsch ^[13] ; Qin,Zhang ^[14] ; Mohamed A,Kamal ^[14] ; John D,Davis ^[14] ; Bolanle,Akinlade ^[14] ; Heribert,Staudinger ^[15] ; Jennifer D,Hamilton ^[14] ; Neil M H,Graham ^[14] ; Gianluca,Pirozzi ^[15] ; Abhijit,Gadkari ^[14] ; Laurent,Eckert ^[16] ; Neil,Stahl ^[14] ; George D,Yancopoulos ^[14] ; Marcella,Ruddy ^[14] ; Ashish,Bansal ^[14]

作者单位： Department of Dermatology, Oregon Health & Science University, Portland. ^[1] Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.;Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois. ^[2] Department of Pediatrics, School of Medicine, Saint Louis University, St. Louis, Missouri. ^[3] Department of Pediatrics, National Jewish Health and University of Colorado School of Medicine, Denver. ^[4] Peninsula Research Associates, Rolling Hills Estates, California. ^[5] Skin Centre for Dermatology, Peterborough, Ontario, Canada.;Department of Medicine, Queen's University, Kingston, Ontario, Canada.;Probity Medical Research, Waterloo, Ontario, Canada. ^[6] Department of Dermatology, University of Rochester Medical Center, Rochester, New York. ^[7] Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York.;Laboratory for Inflammatory Skin Diseases, Icahn School of Medicine at Mount Sinai, New York, New York.;Laboratory for Investigative Dermatology, Rockefeller University, New York, New York. ^[8] Department of Dermatology, Eastern Virginia Medical School, Norfolk. ^[9] Oregon Medical Research Center, Portland. ^[10] Advanced Medical Research, Atlanta, Georgia. ^[11] US Dermatology Partners, Rockville, Maryland.;Georgetown University, Washington, District of Columbia. ^[12] Sanofi Genzyme, Cambridge, Massachusetts. ^[13] Regeneron Pharmaceuticals Inc, Tarrytown, New York. ^[14] Sanofi, Bridgewater, New Jersey. ^[15] Sanofi, Chilly-Mazarin, France. ^[16]

医学主题词青少年(Adolescent);消炎药(Anti-Inflammatory Agents);加拿大(Canada);结膜炎(Conjunctivitis);皮炎, 特应性(Dermatitis, Atopic);剂量效应关系, 药物(Dose-Response Relationship, Drug);双盲法(Double-Blind Method);用药计划表(Drug Administration Schedule);女(雌)性(Female);人类(Humans);注射, 皮下(Injections, Subcutaneous);男(雄)性(Male);生活质量(Quality of Life);疾病严重程度指数(Severity of Illness Index);治疗结果(Treatment Outcome);美国(United States)

DOI 10.1001/jamadermatol.2019.3336

PMID 31693077

发布时间 2024-08-17

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JAMA dermatology

2020年156卷1期

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JAMA dermatology

2020年156卷1期

44-56页

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Efficacy and Safety of Dupilumab in Adolescents With Uncontrolled Moderate to Severe Atopic Dermatitis: A Phase 3 Randomized Clinical Trial.

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Efficacy and Safety of Dupilumab in Adolescents With Uncontrolled Moderate to Severe Atopic Dermatitis: A Phase 3 Randomized Clinical Trial.

JAMA dermatology

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