换一批
换一批Genomic Profiling of Childhood Tumor Patient-Derived Xenograft Models to Enable Rational Clinical Trial Design.
作者：
Jo Lynne,Rokita [1]
;
Komal S,Rathi [2]
;
Maria F,Cardenas [3]
;
Kristen A,Upton [4]
;
Joy,Jayaseelan [3]
;
Katherine L,Cross [5]
;
Jacob,Pfeil [6]
;
Laura E,Egolf [7]
;
Gregory P,Way [8]
;
Alvin,Farrel [9]
;
Nathan M,Kendsersky [10]
;
Khushbu,Patel [9]
;
Krutika S,Gaonkar [2]
;
Apexa,Modi [11]
;
Esther R,Berko [4]
;
Gonzalo,Lopez [12]
;
Zalman,Vaksman [9]
;
Chelsea,Mayoh [13]
;
Jonas,Nance [14]
;
Kristyn,McCoy [14]
;
Michelle,Haber [13]
;
Kathryn,Evans [13]
;
Hannah,McCalmont [13]
;
Katerina,Bendak [13]
;
Julia W,Böhm [13]
;
Glenn M,Marshall [15]
;
Vanessa,Tyrrell [16]
;
Karthik,Kalletla [2]
;
Frank K,Braun [17]
;
Lin,Qi [18]
;
Yunchen,Du [18]
;
Huiyuan,Zhang [18]
;
Holly B,Lindsay [18]
;
Sibo,Zhao [18]
;
Jack,Shu [18]
;
Patricia,Baxter [18]
;
Christopher,Morton [19]
;
Dias,Kurmashev [20]
;
Siyuan,Zheng [20]
;
Yidong,Chen [20]
;
Jay,Bowen [21]
;
Anthony C,Bryan [21]
;
Kristen M,Leraas [21]
;
Sara E,Coppens [21]
;
HarshaVardhan,Doddapaneni [3]
;
Zeineen,Momin [3]
;
Wendong,Zhang [22]
;
Gregory I,Sacks [4]
;
Lori S,Hart [4]
;
Kateryna,Krytska [4]
;
Yael P,Mosse [4]
;
Gregory J,Gatto [23]
;
Yolanda,Sanchez [24]
;
Casey S,Greene [25]
;
Sharon J,Diskin [12]
;
Olena Morozova,Vaske [26]
;
David,Haussler [27]
;
Julie M,Gastier-Foster [28]
;
E Anders,Kolb [29]
;
Richard,Gorlick [22]
;
Xiao-Nan,Li [30]
;
C Patrick,Reynolds [14]
;
Raushan T,Kurmasheva [20]
;
Peter J,Houghton [20]
;
Malcolm A,Smith [31]
;
Richard B,Lock [16]
;
Pichai,Raman [2]
;
David A,Wheeler [3]
;
John M,Maris [32]
作者单位：
Division of Oncology, Children's Hospital of Philadelphia, and Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104-4318, USA; Department of Bioinformatics and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
[1]
Department of Bioinformatics and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
[2]
Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA.
[3]
Division of Oncology, Children's Hospital of Philadelphia, and Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104-4318, USA.
[4]
Guardian Forensic Sciences, Abington, PA 19001, USA.
[5]
UC Santa Cruz Genomics Institute, University of California, Santa Cruz, Santa Cruz, CA 95064, USA.
[6]
Division of Oncology, Children's Hospital of Philadelphia, and Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104-4318, USA; Cell and Molecular Biology Graduate Group, University of Pennsylvania, Philadelphia, PA 19104, USA.
[7]
Genomics and Computational Biology Graduate Group, University of Pennsylvania, Philadelphia, PA 19104, USA.
[8]
Department of Bioinformatics and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
[9]
Division of Oncology, Children's Hospital of Philadelphia, and Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104-4318, USA; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA.
[10]
Division of Oncology, Children's Hospital of Philadelphia, and Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104-4318, USA; Genomics and Computational Biology Graduate Group, University of Pennsylvania, Philadelphia, PA 19104, USA.
[11]
Division of Oncology, Children's Hospital of Philadelphia, and Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104-4318, USA; Department of Bioinformatics and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
[12]
Children's Cancer Institute, School of Women's and Children's Health, UNSW Sydney, Sydney, NSW, Australia.
[13]
Cancer Center, Texas Tech University Health Sciences Center School of Medicine, Lubbock, TX 79430, USA.
[14]
Children's Cancer Institute, School of Women's and Children's Health, UNSW Sydney, Sydney, NSW, Australia; Sydney Children's Hospital, Sydney, NSW, Australia.
[15]
Children's Cancer Institute, Kensington, NSW, Australia.
[16]
Texas Children's Cancer and Hematology Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.
[17]
Preclinical Neurooncology Research Program, Texas Children's Cancer Research Center, Texas Children's Hospital, Houston, TX 77030, USA; Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.
[18]
Department of Surgery, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
[19]
Greehey Children's Cancer Research Institute, University of Texas Health Science Center, San Antonio, TX 78229, USA.
[20]
The Research Institute at Nationwide Children's Hospital, Columbus, OH 43205, USA.
[21]
Division of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
[22]
Department of Global Health Technologies, RTI International, Research Triangle Park, NC 27709, USA.
[23]
Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USA; Norris Cotton Cancer Center, Lebanon, NH 03766, USA.
[24]
Childhood Cancer Data Lab, Alex's Lemonade Stand Foundation, Philadelphia, PA 19102, USA; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA.
[25]
Department of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, Santa Cruz, CA 95064, USA; UC Santa Cruz Genomics Institute, University of California, Santa Cruz, Santa Cruz, CA 95064, USA.
[26]
UC Santa Cruz Genomics Institute, University of California, Santa Cruz, Santa Cruz, CA 95064, USA; Howard Hughes Medical Institute, University of California, Santa Cruz, Santa Cruz, CA 95064, USA.
[27]
The Research Institute at Nationwide Children's Hospital, Columbus, OH 43205, USA; The Ohio State University College of Medicine, Departments of Pathology and Pediatrics, Columbus, OH 43210, USA.
[28]
Department of Pediatrics, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA 19107, USA; Nemours Center for Cancer and Blood Disorders, Nemours/Alfred I. duPont Hospital for Children, Wilmington, DE 19803, USA.
[29]
Preclinical Neurooncology Research Program, Texas Children's Cancer Research Center, Texas Children's Hospital, Houston, TX 77030, USA; Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA; Division of Hematology, Oncology, Neuro-oncology and Stem Cell Transplant, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL 60611, USA; Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
[30]
National Cancer Institute, NIH, Bethesda, MD 20814, USA.
[31]
Division of Oncology, Children's Hospital of Philadelphia, and Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104-4318, USA. Electronic address: maris@email.chop.edu.
[32]
主题词
动物(Animals);细胞系, 肿瘤(Cell Line, Tumor);中枢神经系统肿瘤(Central Nervous System Neoplasms);儿童(Child);临床试验(主题)(Clinical Trials as Topic);疾病模型, 动物(Disease Models, Animal);基因组学(Genomics);人类(Humans);小鼠(Mice);突变(Mutation);神经母细胞瘤(Neuroblastoma);神经纤维素1(Neurofibromin 1);骨肉瘤(Osteosarcoma);前体细胞淋巴母细胞白血病淋巴瘤(Precursor Cell Lymphoblastic Leukemia-Lymphoma);复发(Recurrence);横纹肌肉瘤(Rhabdomyosarcoma);肿瘤抑制蛋白质p53(Tumor Suppressor Protein p53);Wilms瘤(Wilms Tumor);异种移植模型抗肿瘤试验(Xenograft Model Antitumor Assays)
DOI
10.1016/j.celrep.2019.09.071
PMID
31693904
发布时间
2024-09-22
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Cell reports
Cell reports
1675-1689.e9页
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