换一批HDAC4 and HDAC5 form a complex with DREAM that epigenetically down-regulates NCX3 gene and its pharmacological inhibition reduces neuronal stroke damage.
第一作者：
Luigi,Formisano
第一单位：
Division of Pharmacology, Department of Neuroscience, Reproductive and Dentistry Sciences, School of Medicine, "Federico II" University of Naples, Naples, Italy.
作者：
医学主题词
动物(Animals);大脑皮质(Cerebral Cortex);后成说, 遗传(Epigenesis, Genetic);基因表达调控(Gene Expression Regulation);基因敲低技术(Gene Knockdown Techniques);组蛋白脱乙酰基酶抑制剂(Histone Deacetylase Inhibitors);组蛋白脱乙酰基酶类(Histone Deacetylases);人类(Humans);缺氧, 脑(Hypoxia, Brain);梗死, 大脑中动脉(Infarction, Middle Cerebral Artery);Kv通道调节蛋白质类(Kv Channel-Interacting Proteins);男(雄)性(Male);神经元(Neurons);神经保护药(Neuroprotective Agents);RNA, 小分子干扰(RNA, Small Interfering);大鼠(Rats);大鼠, Sprague-Dawley(Rats, Sprague-Dawley);阻遏蛋白质类(Repressor Proteins);钠钙交换蛋白(Sodium-Calcium Exchanger);卒中(Stroke)
DOI
10.1177/0271678X19884742
PMID
31696766
发布时间
2021-08-20
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