Identification of novel risk loci, causal insights, and heritable risk for Parkinson's disease: a meta-analysis of genome-wide association studies.
第一作者:
Mike A,Nalls
第一单位:
Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA; Data Tecnica International, Glen Echo, MD, USA. Electronic address: mike@datatecnica.com.
作者:
Mike A,Nalls [1]
;
Cornelis,Blauwendraat [2]
;
Costanza L,Vallerga [3]
;
Karl,Heilbron [4]
;
Sara,Bandres-Ciga [2]
;
Diana,Chang [5]
;
Manuela,Tan [6]
;
Demis A,Kia [6]
;
Alastair J,Noyce [7]
;
Angli,Xue [8]
;
Jose,Bras [9]
;
Emily,Young [10]
;
Rainer,von Coelln [11]
;
Javier,Simón-Sánchez [12]
;
Claudia,Schulte [12]
;
Manu,Sharma [13]
;
Lynne,Krohn [14]
;
Lasse,Pihlstrøm [15]
;
Ari,Siitonen [16]
;
Hirotaka,Iwaki [17]
;
Hampton,Leonard [18]
;
Faraz,Faghri [19]
;
J Raphael,Gibbs [2]
;
Dena G,Hernandez [2]
;
Sonja W,Scholz [20]
;
Juan A,Botia [21]
;
Maria,Martinez [22]
;
Jean-Christophe,Corvol [23]
;
Suzanne,Lesage [23]
;
Joseph,Jankovic [10]
;
Lisa M,Shulman [11]
;
Margaret,Sutherland [24]
;
Pentti,Tienari [25]
;
Kari,Majamaa [16]
;
Mathias,Toft [26]
;
Ole A,Andreassen [27]
;
Tushar,Bangale [5]
;
Alexis,Brice [23]
;
Jian,Yang [8]
;
Ziv,Gan-Or [28]
;
Thomas,Gasser [12]
;
Peter,Heutink [12]
;
Joshua M,Shulman [29]
;
Nicholas W,Wood [6]
;
David A,Hinds [4]
;
John A,Hardy [30]
;
Huw R,Morris [31]
;
Jacob,Gratten [32]
;
Peter M,Visscher [8]
;
Robert R,Graham [5]
;
Andrew B,Singleton [2]
;
23andMe Research Team ;
System Genomics of Parkinson's Disease Consortium ;
International Parkinson's Disease Genomics Consortium
作者单位:
Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA; Data Tecnica International, Glen Echo, MD, USA. Electronic address: mike@datatecnica.com.
[1]
Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
[2]
Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia.
[3]
23andMe, Sunnyvale, CA, USA.
[4]
Department of Human Genetics, Genentech, South San Francisco, CA, USA.
[5]
Department of Molecular Neuroscience, UCL Queen Square Institute of Neurology, London, UK; Department of Clinical and Movement Neuroscience and UCL Movement Disorders Centre, UCL Queen Square Institute of Neurology, London, UK.
[6]
Department of Molecular Neuroscience, UCL Queen Square Institute of Neurology, London, UK; Preventive Neurology Unit, Wolfson Institute of Preventive Medicine, Queen Mary University of London, London, UK.
[7]
Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia.
[8]
Department of Neurodegenerative Diseases, UCL Queen Square Institute of Neurology, London, UK; Center for Neurodegenerative Science, Van Andel Research Institute, Grand Rapids, MI, USA.
[9]
Department of Neurology, Baylor College of Medicine, Houston, TX, USA.
[10]
Department of Neurology, University of Maryland School of Medicine, Baltimore, MD, USA.
[11]
Department for Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany; German Center for Neurodegenerative Diseases, Tübingen, Germany.
[12]
Centre for Genetic Epidemiology, Institute for Clinical Epidemiology and Applied Biometry, University of Tübingen, Tübingen, Germany.
[13]
Department of Human Genetics, McGill University, Montreal, QC, Canada; Montreal Neurological Institute, McGill University, Montreal, QC, Canada.
[14]
Department of Neurology, Oslo University Hospital, Oslo, Norway.
[15]
Institute of Clinical Medicine, Department of Neurology, University of Oulu, Oulu, Finland; Department of Neurology and Medical Research Center, Oulu University Hospital, Oulu, Finland.
[16]
Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA; Data Tecnica International, Glen Echo, MD, USA; The Michael J Fox Foundation, New York, NY, USA.
[17]
Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA; Data Tecnica International, Glen Echo, MD, USA.
[18]
Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA; Department of Computer Science, University of Illinois Urbana-Champaign, Champaign, IL, USA.
[19]
National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA; Department of Neurology, Johns Hopkins University Medical Center, Baltimore, MD, USA.
[20]
Department of Molecular Neuroscience, UCL Queen Square Institute of Neurology, London, UK; Departamento de Ingeniería de la Información y las Comunicaciones, Universidad de Murcia, Spain.
[21]
Institut national de la santé et de la recherche médicale Unité mixte de recherche 1220, Toulouse, France; Paul Sabatier University, Toulouse, France.
[22]
Institut national de la santé et de la recherche médicale U1127, CNRS UMR 7225, Paris, France; Sorbonne Université centre national de la recherche médicale, unité mixte de recherche 1127, Paris, France; Assistance Publique Hôpitaux de Paris, Paris, France; Institut du Cerveau et de la Moelle épinière, Paris, France.
[23]
National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
[24]
Clinical Neurosciences, Neurology, University of Helsinki, Helsinki, Finland; Helsinki University Hospital, Helsinki, Finland.
[25]
Department of Neurology, Oslo University Hospital, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
[26]
Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway; Jebsen Centre for Psychosis Research, University of Oslo, Oslo, Norway.
[27]
Department of Human Genetics, McGill University, Montreal, QC, Canada; Montreal Neurological Institute, McGill University, Montreal, QC, Canada; Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada.
[28]
Department of Neurology, Baylor College of Medicine, Houston, TX, USA; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA; Department of Neuroscience, Baylor College of Medicine, Houston, TX, USA; Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX, USA.
[29]
Department of Molecular Neuroscience, UCL Queen Square Institute of Neurology, London, UK.
[30]
Department of Clinical and Movement Neuroscience and UCL Movement Disorders Centre, UCL Queen Square Institute of Neurology, London, UK.
[31]
Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia; Mater Research Institute, The University of Queensland, Brisbane, QLD, Australia.
[32]
主题词
数据库, 遗传学(Databases, Genetic);基因座(Genetic Loci);疾病遗传易感性(Genetic Predisposition to Disease);全基因组关联研究(Genome-Wide Association Study);人类(Humans);帕金森病(Parkinson Disease);危险因素(Risk Factors)
DOI
10.1016/S1474-4422(19)30320-5
PMID
31701892
发布时间
2023-02-16
- 浏览6

The Lancet. Neurology
The Lancet. Neurology
1091-1102页
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