Inhibition of mTOR Signaling Enhances Maturation of Cardiomyocytes Derived From Human-Induced Pluripotent Stem Cells via p53-Induced Quiescence.

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第一作者： Jessica C,Garbern

第一单位： Department of Stem Cell and Regenerative Biology and the Harvard Stem Cell Institute (J.C.G., A.H., R.S., M.S., A.A., G.O.E., D.A.M., R.T.L.), Harvard University, Cambridge, MA.

作者： Jessica C,Garbern ^[1] ; Aharon,Helman ^[2] ; Rebecca,Sereda ^[1] ; Mohsen,Sarikhani ^[1] ; Aishah,Ahmed ^[1] ; Gabriela O,Escalante ^[1] ; Roza,Ogurlu ^[1] ; Sean L,Kim ^[2] ; John F,Zimmerman ^[1] ; Alexander,Cho ^[3] ; Luke,MacQueen ^[3] ; Vassilios J,Bezzerides ^[3] ; Kevin Kit,Parker ^[3] ; Douglas A,Melton ^[2] ; Richard T,Lee ^[3]

作者单位： Department of Stem Cell and Regenerative Biology and the Harvard Stem Cell Institute (J.C.G., A.H., R.S., M.S., A.A., G.O.E., D.A.M., R.T.L.), Harvard University, Cambridge, MA. ^[1] Department of Cardiology, Boston Children's Hospital, MA (J.C.G., R.O., V.J.B.). ^[2] Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, School of Engineering and Applied Sciences (S.L.K., J.F.Z., A.C., L.M., K.K.P.), Harvard University, Cambridge, MA. ^[3] Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (R.T.L.). ^[4]

关键词 MTOR protein induced pluripotent stem cells myocytes, cardiac stem cells troponin I