首页> Archives of toxicology> Development of a neural rosette formation assay (RoFA) to identify neurodevelopmental toxicants and to characterize their transcriptome disturbances.

Development of a neural rosette formation assay (RoFA) to identify neurodevelopmental toxicants and to characterize their transcriptome disturbances.

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第一作者： Nadine,Dreser

第一单位： In Vitro Toxicology and Biomedicine, Department Inaugurated By the Doerenkamp-Zbinden Chair Foundation, University of Konstanz, Box 657, 78457, Konstanz, Germany.

作者： Nadine,Dreser ^[1] ; Katrin,Madjar ^[2] ; Anna-Katharina,Holzer ^[1] ; Marion,Kapitza ^[1] ; Christopher,Scholz ^[1] ; Petra,Kranaster ^[3] ; Simon,Gutbier ^[4] ; Stefanie,Klima ^[1] ; David,Kolb ^[5] ; Christian,Dietz ^[5] ; Timo,Trefzer ^[6] ; Johannes,Meisig ^[7] ; Christoph,van Thriel ^[8] ; Margit,Henry ^[9] ; Michael R,Berthold ^[10] ; Nils,Blüthgen ^[7] ; Agapios,Sachinidis ^[9] ; Jörg,Rahnenführer ^[2] ; Jan G,Hengstler ^[8] ; Tanja,Waldmann ^[1] ; Marcel,Leist ^[11]

作者单位： In Vitro Toxicology and Biomedicine, Department Inaugurated By the Doerenkamp-Zbinden Chair Foundation, University of Konstanz, Box 657, 78457, Konstanz, Germany. ^[1] Department of Statistics, TU Dortmund, 44221, Dortmund, Germany. ^[2] In Vitro Toxicology and Biomedicine, Department Inaugurated By the Doerenkamp-Zbinden Chair Foundation, University of Konstanz, Box 657, 78457, Konstanz, Germany.;Konstanz Research School Chemical Biology (KoRS-CB), University of Konstanz, 78457, Konstanz, Germany. ^[3] In Vitro Toxicology and Biomedicine, Department Inaugurated By the Doerenkamp-Zbinden Chair Foundation, University of Konstanz, Box 657, 78457, Konstanz, Germany.;Roche Pharma Development, Grenzacherstrasse, 4070, Basel, Switzerland. ^[4] Department of Computer and Information Science, University of Konstanz, 78457, Konstanz, Germany.;KNIME GmbH, 78467, Konstanz, Germany. ^[5] In Vitro Toxicology and Biomedicine, Department Inaugurated By the Doerenkamp-Zbinden Chair Foundation, University of Konstanz, Box 657, 78457, Konstanz, Germany.;Digital Health Center, Berlin Institute of Health (BIH), Charité-Universitätsmedizin, 10117, Berlin, Germany. ^[6] Institute of Pathology, Charité-Universitätsmedizin, 10117, Berlin, Germany. ^[7] Leibniz Research Centre for Working Environment and Human Factors (IfADo), Technical University of Dortmund, 44139, Dortmund, Germany. ^[8] Center of Physiology and Pathophysiology, Institute of Neurophysiology, University of Cologne (UKK), 50931, Cologne, Germany. ^[9] Department of Computer and Information Science, University of Konstanz, 78457, Konstanz, Germany. ^[10] In Vitro Toxicology and Biomedicine, Department Inaugurated By the Doerenkamp-Zbinden Chair Foundation, University of Konstanz, Box 657, 78457, Konstanz, Germany. Marcel.leist@uni-konstanz.de. ^[11]

关键词 Cytotoxicity Developmental toxicity Differentiation Gene expression Human stem cells Neural precursor cells Neural rosettes Phenotypic anchoring