Recent advances in the pathogenesis of hereditary fructose intolerance: implications for its treatment and the understanding of fructose-induced non-alcoholic fatty liver disease.

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第一作者： Amée M,Buziau

第一单位： Division of Endocrinology, Department of Internal Medicine, Maastricht University Medical Center, Maastricht, The Netherlands.;Laboratory for Metabolism and Vascular Medicine, Division of General Internal Medicine, Department of Internal Medicine, Maastricht University Medical Center, Maastricht, The Netherlands.;Cardiovascular Research Institute Maastricht (CARIM), Maastricht, The Netherlands.

作者： Amée M,Buziau ^[1] ; Casper G,Schalkwijk ^[2] ; Coen D A,Stehouwer ^[3] ; Dean R,Tolan ^[4] ; Martijn C G J,Brouwers ^[5]

作者单位： Division of Endocrinology, Department of Internal Medicine, Maastricht University Medical Center, Maastricht, The Netherlands.;Laboratory for Metabolism and Vascular Medicine, Division of General Internal Medicine, Department of Internal Medicine, Maastricht University Medical Center, Maastricht, The Netherlands.;Cardiovascular Research Institute Maastricht (CARIM), Maastricht, The Netherlands. ^[1] Laboratory for Metabolism and Vascular Medicine, Division of General Internal Medicine, Department of Internal Medicine, Maastricht University Medical Center, Maastricht, The Netherlands.;Cardiovascular Research Institute Maastricht (CARIM), Maastricht, The Netherlands. ^[2] Laboratory for Metabolism and Vascular Medicine, Division of General Internal Medicine, Department of Internal Medicine, Maastricht University Medical Center, Maastricht, The Netherlands.;Cardiovascular Research Institute Maastricht (CARIM), Maastricht, The Netherlands.;Division of General Internal Medicine, Department of Internal Medicine, Maastricht University Medical Center, Maastricht, The Netherlands. ^[3] Department of Biology, Boston University, Boston, MA, USA. tolan@bu.edu. ^[4] Division of Endocrinology, Department of Internal Medicine, Maastricht University Medical Center, Maastricht, The Netherlands. mcgj.brouwers@mumc.nl.;Laboratory for Metabolism and Vascular Medicine, Division of General Internal Medicine, Department of Internal Medicine, Maastricht University Medical Center, Maastricht, The Netherlands. mcgj.brouwers@mumc.nl.;Cardiovascular Research Institute Maastricht (CARIM), Maastricht, The Netherlands. mcgj.brouwers@mumc.nl. ^[5]

关键词 De novo lipogenesis Fructose Glucokinase regulatory protein Hereditary fructose intolerance Ketohexokinase Non-alcoholic fatty liver disease

主题词动物(Animals);果糖(Fructose);果糖不耐受(Fructose Intolerance);疾病遗传易感性(Genetic Predisposition to Disease);人类(Humans);小鼠(Mice)

DOI 10.1007/s00018-019-03348-2

PMID 31713637

发布时间 2024-05-22

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