Enhanced Clearing of Wound-Related Pathogenic Bacterial Biofilms Using Protease-Functionalized Antibiotic Nanocarriers.

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作者： Paul J,Weldrick ^[1] ; Matthew J,Hardman ^[2] ; Vesselin N,Paunov ^[1]

作者单位： Department of Chemistry and Biochemistry , University of Hull , Hull HU6 7RX , U.K. ^[1] Centre for Atherothrombosis and Metabolic Disease , Hull York Medical School , Hull HU6 7RX , U.K. ^[2]

关键词 Alcalase 2.4 L FG Klebsiella pneumoniae Pseudomonas aeruginosa Staphylococcus aureus biofilms ciprofloxacin nanogels protease

主题词抗菌药(Anti-Bacterial Agents);细菌感染(Bacterial Infections);生物催化(Biocatalysis);生物膜(Biofilms);环丙沙星(Ciprofloxacin);药物载体(Drug Carriers);药物释放系统(Drug Delivery Systems);大肠杆菌(Escherichia coli);人类(Humans);肺炎克雷伯菌(Klebsiella pneumoniae);微生物敏感性试验(Microbial Sensitivity Tests);聚乙烯二醇类(Polyethylene Glycols);聚乙烯亚胺(Polyethyleneimine);铜绿假单胞菌(Pseudomonas aeruginosa);金黄色葡萄球菌(Staphylococcus aureus);枯草杆菌蛋白酶类(Subtilisins);伤口感染(Wound Infection)

DOI 10.1021/acsami.9b16119

PMID 31718141

发布时间 2020-04-08

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ACS applied materials & interfaces

2019年11卷47期

43902-43919页

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Enhanced Clearing of Wound-Related Pathogenic Bacterial Biofilms Using Protease-Functionalized Antibiotic Nanocarriers.

ACS applied materials & interfaces

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Enhanced Clearing of Wound-Related Pathogenic Bacterial Biofilms Using Protease-Functionalized Antibiotic Nanocarriers.

ACS applied materials & interfaces

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