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Cdr1p highlights the role of the non-hydrolytic ATP-binding site in driving drug translocation in asymmetric ABC pumps.

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第一作者： Atanu,Banerjee

第一单位： Amity Institute of Biotechnology, Amity University Haryana, Gurgaon, India; School of Life Sciences, Jawaharlal Nehru University, New Delhi, India. Electronic address: abanerjee1@ggn.amity.edu.

作者： Atanu,Banerjee ^[1] ; Alexis,Moreno ^[2] ; Mohammad Firoz,Khan ^[3] ; Remya,Nair ^[4] ; Suman,Sharma ^[4] ; Sobhan,Sen ^[3] ; Alok Kumar,Mondal ^[5] ; Jorgaq,Pata ^[2] ; Cédric,Orelle ^[6] ; Pierre,Falson ^[7] ; Rajendra,Prasad ^[8]

作者单位： Amity Institute of Biotechnology, Amity University Haryana, Gurgaon, India; School of Life Sciences, Jawaharlal Nehru University, New Delhi, India. Electronic address: abanerjee1@ggn.amity.edu. ^[1] Drug Resistance & Membrane Proteins Team, Molecular Microbiology and Structural Biochemistry Laboratory, CNRS-Lyon 1 University UMR5086, Institut de Biologie et Chimie des Protéines, Lyon, France. ^[2] School of Physical Sciences, Jawaharlal Nehru University, New Delhi, India. ^[3] Amity Institute of Biotechnology, Amity University Haryana, Gurgaon, India. ^[4] School of Life Sciences, Jawaharlal Nehru University, New Delhi, India. ^[5] Bacterial Nucleotide-binding Proteins: Resistance to Antibiotics and New Enzymes Team, Molecular Microbiology and Structural Biochemistry Laboratory, CNRS-Lyon 1 University UMR5086, Institut de Biologie et Chimie des Protéines, Lyon, France. ^[6] Bacterial Nucleotide-binding Proteins: Resistance to Antibiotics and New Enzymes Team, Molecular Microbiology and Structural Biochemistry Laboratory, CNRS-Lyon 1 University UMR5086, Institut de Biologie et Chimie des Protéines, Lyon, France. Electronic address: pierre.falson@ibcp.fr. ^[7] Amity Institute of Biotechnology, Amity University Haryana, Gurgaon, India; Amity Institute of Integrative Sciences and Health, Amity University Haryana, Gurgaon, India. Electronic address: rp47jnu@gmail.com. ^[8]

关键词 ABC signature sequence ABC transporter Antifungal drug resistance Candida albicans Non-hydrolytic nucleotide-binding site