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A technique for delineating the unfolding requirements for substrate entry into retrotranslocons during endoplasmic reticulum-associated degradation.

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第一作者： Junfen,Shi

第一单位： Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201210, China.;University of Chinese Academy of Sciences, Shijingshan District, Beijing 100049, China.

作者： Junfen,Shi ^[1] ; Xianyan,Hu ^[1] ; Yuan,Guo ^[1] ; Linhan,Wang ^[1] ; Jia,Ji ^[1] ; Jiqiang,Li ^[1] ; Zai-Rong,Zhang ^[2]

作者单位： Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201210, China.;University of Chinese Academy of Sciences, Shijingshan District, Beijing 100049, China. ^[1] Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201210, China zrzhang@sioc.ac.cn.;University of Chinese Academy of Sciences, Shijingshan District, Beijing 100049, China. ^[2]

关键词 E3 ubiquitin ligase ER quality control ER-associated degradation ER-to-cytosol transport dihydrofolate reductase membrane enzyme protein misfolding retrotranslocation tunable folding domain ubiquitylation (ubiquitination)unfolded substrate