Circular ecDNA promotes accessible chromatin and high oncogene expression.

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作者： Sihan,Wu ^[1] ; Kristen M,Turner ^[1] ; Nam,Nguyen ^[2] ; Ramya,Raviram ^[3] ; Marcella,Erb ^[2] ; Jennifer,Santini ^[1] ; Jens,Luebeck ^[4] ; Utkrisht,Rajkumar ^[4] ; Yarui,Diao ^[5] ; Bin,Li ^[3] ; Wenjing,Zhang ^[1] ; Nathan,Jameson ^[6] ; M Ryan,Corces ^[7] ; Jeffrey M,Granja ^[1] ; Xingqi,Chen ^[1] ; Ceyda,Coruh ^[1] ; Armen,Abnousi ^[8] ; Jack,Houston ^[8] ; Zhen,Ye ^[8] ; Rong,Hu ^[9] ; Miao,Yu ^[10] ; Hoon,Kim ^[11] ; Julie A,Law ^[1] ; Roel G W,Verhaak ^[1] ; Ming,Hu ^[1] ; Frank B,Furnari ^[1] ; Howard Y,Chang ^[12] ; Bing,Ren ^[10] ; Vineet,Bafna ^[12] ; Paul S,Mischel ^[11]

作者单位： Ludwig Institute for Cancer Research, University of California at San Diego, La Jolla, CA, USA. ^[1] Boundless Bio, Inc., La Jolla, CA, USA. ^[2] Department of Computer Science and Engineering, University of California at San Diego, La Jolla, CA, USA. ^[3] UCSD Light Microscopy Core Facility, Department of Neurosciences, University of California at San Diego, La Jolla, CA, USA. ^[4] Bioinformatics & Systems Biology Graduate Program, University of California at San Diego, La Jolla, CA, USA. ^[5] Department of Cell Biology, Regeneration Next Initiative, Duke University School of Medicine, Durham, NC, USA. ^[6] Department of Orthopaedic Surgery, Regeneration Next Initiative, Duke University School of Medicine, Durham, NC, USA. ^[7] Center for Personal Dynamic Regulomes, Stanford University, Stanford, CA, USA. ^[8] Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden. ^[9] Plant Molecular and Cellular Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA. ^[10] Department of Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, USA. ^[11] The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA. ^[12] Center for Personal Dynamic Regulomes, Stanford University, Stanford, CA, USA. howchang@stanford.edu. ^[13] Howard Hughes Medical Institute, Stanford University, Stanford, CA, USA. howchang@stanford.edu. ^[14] Ludwig Institute for Cancer Research, University of California at San Diego, La Jolla, CA, USA. biren@ucsd.edu. ^[15] Department of Cellular and Molecular Medicine, Center for Epigenomics, University of California at San Diego, La Jolla, CA, USA. biren@ucsd.edu. ^[16] Institute of Genomic Medicine, Moores Cancer Center, University of California at San Diego, La Jolla, CA, USA. biren@ucsd.edu. ^[17] Department of Computer Science and Engineering, University of California at San Diego, La Jolla, CA, USA. vbafna@cs.ucsd.edu. ^[18] Ludwig Institute for Cancer Research, University of California at San Diego, La Jolla, CA, USA. pmischel@ucsd.edu. ^[19] Moores Cancer Center, University of California at San Diego, La Jolla, CA, USA. pmischel@ucsd.edu. ^[20] Department of Pathology, University of California at San Diego, La Jolla, CA, USA. pmischel@ucsd.edu. ^[21]