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Genetic predisposition to mosaic Y chromosome loss in blood.

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第一作者： Deborah J,Thompson

第一单位： Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.

作者： Deborah J,Thompson ^[1] ; Giulio,Genovese ^[2] ; Jonatan,Halvardson ^[3] ; Jacob C,Ulirsch ^[4] ; Daniel J,Wright ^[5] ; Chikashi,Terao ^[6] ; Olafur B,Davidsson ^[7] ; Felix R,Day ^[8] ; Patrick,Sulem ^[7] ; Yunxuan,Jiang ^[9] ; Marcus,Danielsson ^[3] ; Hanna,Davies ^[3] ; Joe,Dennis ^[1] ; Malcolm G,Dunlop ^[10] ; Douglas F,Easton ^[1] ; Victoria A,Fisher ^[11] ; Florian,Zink ^[7] ; Richard S,Houlston ^[12] ; Martin,Ingelsson ^[13] ; Siddhartha,Kar ^[14] ; Nicola D,Kerrison ^[15] ; Ben,Kinnersley ^[12] ; Ragnar P,Kristjansson ^[7] ; Philip J,Law ^[12] ; Rong,Li ^[16] ; Chey,Loveday ^[12] ; Jonas,Mattisson ^[3] ; Steven A,McCarroll ^[2] ; Yoshinori,Murakami ^[17] ; Anna,Murray ^[18] ; Pawel,Olszewski ^[19] ; Edyta,Rychlicka-Buniowska ^[20] ; Robert A,Scott ^[15] ; Unnur,Thorsteinsdottir ^[21] ; Ian,Tomlinson ^[22] ; Behrooz Torabi,Moghadam ^[3] ; Clare,Turnbull ^[23] ; Nicholas J,Wareham ^[15] ; Daniel F,Gudbjartsson ^[24] ; International Lung Cancer Consortium (INTEGRAL-ILCCO) ^[25] ; Breast Cancer Association Consortium ^[26] ; Consortium of Investigators of Modifiers of BRCA1/2 ^[27] ; Endometrial Cancer Association Consortium ^[21] ; Ovarian Cancer Association Consortium ^[9] ; Prostate Cancer Association Group to Investigate Cancer Associated Alterations in the Genome (PRACTICAL) Consortium ^[15] ; Kidney Cancer GWAS Meta-Analysis Project ^[11] ; eQTLGen Consortium ^[28] ; Biobank-based Integrative Omics Study (BIOS) Consortium ^[20] ; 23andMe Research Team ^[11] ; Yoichiro,Kamatani ^[29] ; Eva R,Hoffmann ^[30] ; Steve P,Jackson ; Kari,Stefansson ; Adam,Auton ; Ken K,Ong ; Mitchell J,Machiela ; Po-Ru,Loh ; Jan P,Dumanski ; Stephen J,Chanock ; Lars A,Forsberg ; John R B,Perry

作者单位： Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. ^[1] Department of Genetics, Harvard Medical School, Boston, MA, USA.;Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.;Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA. ^[2] Department of Immunology, Genetics and Pathology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden. ^[3] Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.;Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, MA, USA. ^[4] MRC Epidemiology Unit, School of Clinical Medicine, University of Cambridge, Cambridge, UK.;Open Targets Core Genetics, Wellcome Sanger Institute, Hinxton, UK. ^[5] Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan.;Clinical Research Center, Shizuoka General Hospital, Shizuoka, Japan.;Department of Applied Genetics, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan.;Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan. ^[6] deCODE Genetics, Amgen, Reykjavík, Iceland. ^[7] MRC Epidemiology Unit, School of Clinical Medicine, University of Cambridge, Cambridge, UK.;Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands. ^[8] 23andMe, Mountain View, CA, USA. ^[9] Colon Cancer Genetics Group, Medical Research Council Human Genetics Unit and CRUK Cancer Research Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK. ^[10] Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA. ^[11] Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK. ^[12] Geriatrics Research Group, Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden. ^[13] Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK. ^[14] MRC Epidemiology Unit, School of Clinical Medicine, University of Cambridge, Cambridge, UK. ^[15] Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. ^[16] Division of Molecular Pathology, Institute of Medical Science, University of Tokyo, Tokyo, Japan. ^[17] Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK. ^[18] Faculty of Pharmacy, Medical University of Gdansk, Gdansk, Poland. ^[19] Department of Immunology, Genetics and Pathology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.;Faculty of Pharmacy, Medical University of Gdansk, Gdansk, Poland. ^[20] deCODE Genetics, Amgen, Reykjavík, Iceland.;Faculty of Medicine, University of Iceland, Reykjavík, Iceland. ^[21] Cancer Genetics and Evolution Laboratory, Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK. ^[22] Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.;William Harvey Research Institute, Queen Mary University, London, UK. ^[23] deCODE Genetics, Amgen, Reykjavík, Iceland.;School of Engineering and Natural Sciences, University of Iceland, Reykjavík, Iceland. ^[24] Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan.;Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan.;Kyoto-McGill International Collaborative School in Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan. ^[25] DNRF Center for Chromosome Stability, Department of Cellular and Molecular Medicine, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark. ^[26] Department of Biochemistry, University of Cambridge, Cambridge, UK.;Wellcome Trust and Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge, UK. ^[27] Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.;Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. ^[28] Department of Immunology, Genetics and Pathology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.;Beijer Laboratory of Genome Research, Uppsala University, Uppsala, Sweden. ^[29] MRC Epidemiology Unit, School of Clinical Medicine, University of Cambridge, Cambridge, UK. john.perry@mrc-epid.cam.ac.uk.;Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands. john.perry@mrc-epid.cam.ac.uk. ^[30]