Deletion of the SAPS1 subunit of protein phosphatase 6 in mice increases radiosensitivity and impairs the cellular DNA damage response.

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作者： Jaroslaw,Dziegielewski ^[1] ; Magdalena A,Bońkowska ^[2] ; Ewa A,Poniecka ^[2] ; Jinho,Heo ^[2] ; Kangping,Du ^[1] ; Rowena B,Crittenden ^[3] ; Timothy P,Bender ^[3] ; David L,Brautigan ^[2] ; James M,Larner ^[4]

作者单位： Center for Cell Signaling, University of Virginia School of Medicine, Charlottesville, VA 22908, USA; Department of Radiation Oncology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA. ^[1] Center for Cell Signaling, University of Virginia School of Medicine, Charlottesville, VA 22908, USA; Department of Microbiology, Immunology and Cancer Biology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA. ^[2] Department of Microbiology, Immunology and Cancer Biology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA; Beirne B. Carter Center for Immunology Research, University of Virginia School of Medicine, Charlottesville, VA 22908, USA. ^[3] Center for Cell Signaling, University of Virginia School of Medicine, Charlottesville, VA 22908, USA; Department of Radiation Oncology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA. Electronic address: JML2P@virginia.edu. ^[4]

关键词 DNA damage response Protein phosphatase 6 Radiosensitivity SAPS1