Discovery of Novel, Potent, Brain-Permeable, and Orally Efficacious Positive Allosteric Modulator of α7 Nicotinic Acetylcholine Receptor [4-(5-(4-Chlorophenyl)-4-methyl-2-propionylthiophen-3-yl)benzenesulfonamide]: Structure-Activity Relationship and Preclinical Characterization.

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作者： Neelima,Sinha ^[1] ; Navnath P,Karche ^[1] ; Mahip Kalyan,Verma ^[1] ; Sameer S,Walunj ^[1] ; Prashant B,Nigade ^[1] ; Gourhari,Jana ^[1] ; Sanjay P,Kurhade ^[1] ; Anil K,Hajare ^[1] ; Ajay R,Tilekar ^[1] ; Ganesh R,Jadhav ^[1] ; Baban R,Thube ^[1] ; Javed S,Shaikh ^[1] ; Sudhakar,Balgude ^[1] ; Lairikyengbam Bikramjit,Singh ^[1] ; Vijaya,Mahimane ^[1] ; Shridhar K,Adurkar ^[1] ; Girish,Hatnapure ^[1] ; Firoj,Raje ^[1] ; Yogesh,Bhosale ^[1] ; Dnyaneshwar,Bhanage ^[1] ; Sachchidanand,Sachchidanand ^[1] ; Ruchi,Dixit ^[1] ; Rajesh,Gupta ^[1] ; Anand M,Bokare ^[1] ; Manoj,Dandekar ^[1] ; Ashish,Bharne ^[1] ; Manavi,Chatterjee ^[1] ; Sagar,Desai ^[1] ; Sarita,Koul ^[1] ; Dipak,Modi ^[1] ; Maneesh,Mehta ^[1] ; Vinod,Patil ^[1] ; Minakshi,Singh ^[1] ; Jayasagar,Gundu ^[1] ; Rajan N,Goel ^[1] ; Chirag,Shah ^[1] ; Sharad,Sharma ^[1] ; Dhananjay,Bakhle ^[1] ; Rajender Kumar,Kamboj ^[1] ; Venkata P,Palle ^[1]

作者单位： Novel Drug Discovery & Development , Lupin Ltd. , Lupin Research Park, Survey No. 46 A/47 A, Village Nande, Taluka Mulshi , Pune 412115 , India. ^[1]