PDS5 proteins are required for proper cohesin dynamics and participate in replication fork protection.

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作者： Carmen,Morales ^[1] ; Miguel,Ruiz-Torres ^[1] ; Sara,Rodríguez-Acebes ^[2] ; Vanesa,Lafarga ^[3] ; Miriam,Rodríguez-Corsino ^[1] ; Diego,Megías ^[4] ; David A,Cisneros ^[5] ; Jan-Michael,Peters ^[5] ; Juan,Méndez ^[2] ; Ana,Losada ^[6]

作者单位： Chromosome Dynamics Group, Spanish National Cancer Research Centre (CNIO), Melchor Fernández Almagro 3, 28029 Madrid, Spain. ^[1] DNA Replication Group, Spanish National Cancer Research Centre (CNIO), Melchor Fernández Almagro 3, 28029 Madrid, Spain. ^[2] Genome Instability Group, Molecular Oncology Programme, Spanish National Cancer Research Centre (CNIO), Melchor Fernández Almagro 3, 28029 Madrid, Spain. ^[3] Confocal Microscopy Unit, Biotechnology Programme, Spanish National Cancer Research Centre (CNIO), Melchor Fernández Almagro 3, 28029 Madrid, Spain. ^[4] Research Institute for Molecular Pathology (IMP), Campus Vienna-Biocenter 1, 1030 Vienna, Austria. ^[5] Chromosome Dynamics Group, Spanish National Cancer Research Centre (CNIO), Melchor Fernández Almagro 3, 28029 Madrid, Spain. Electronic address: alosada@cnio.es. ^[6]

关键词 BRCA2 DNA replication cell cycle cohesin fork protection fork reversal fork stalling genomic instability microscopy replication stress replisome