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A novel class of cardioprotective small-molecule PTP inhibitors.

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第一作者： Salvatore,Antonucci

第一单位： Department of Biomedical Sciences, University of Padova, Padova, Italy.

作者： Salvatore,Antonucci ^[1] ; Moises,Di Sante ^[1] ; Justina,Sileikyte ^[2] ; Jordan,Deveraux ^[2] ; Tyler,Bauer ^[3] ; Michael J,Bround ^[4] ; Roberta,Menabò ^[5] ; Melanie,Paillard ^[6] ; Petra,Alanova ^[7] ; Michela,Carraro ^[1] ; Michel,Ovize ^[6] ; Jeffery D,Molkentin ^[8] ; Michael,Cohen ^[2] ; Michael A,Forte ^[2] ; Paolo,Bernardi ^[5] ; Fabio,Di Lisa ^[9] ; Elizabeth,Murphy ^[10]

作者单位： Department of Biomedical Sciences, University of Padova, Padova, Italy. ^[1] Vollum Institute, and Department of Physiology and Pharmacology, Portland, OR, USA. ^[2] Systems Biology Center, NHLBI, NIH, Bethesda, MD, USA. ^[3] Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH, USA. ^[4] Department of Biomedical Sciences, University of Padova, Padova, Italy; National Research Council of Italy (CNR), Padova, Italy. ^[5] CarMeN Laboratory, University Claude Bernard Lyon 1, INSA Lyon, Oullins, France. ^[6] Department of Biomedical Sciences, University of Padova, Padova, Italy; Department of Developmental Cardiology, Institute of Physiology CAS, Prague, Czech Republic. ^[7] Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH, USA; Howard Hughes Medical Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. ^[8] Department of Biomedical Sciences, University of Padova, Padova, Italy; National Research Council of Italy (CNR), Padova, Italy. Electronic address: dilisa@bio.unipd.it. ^[9] Systems Biology Center, NHLBI, NIH, Bethesda, MD, USA. Electronic address: murphy1@nhlbi.nih.gov. ^[10]

关键词 Caffeine (PubChem CID: 2519)Calcimycin (PubChem CID: 40486)Cardiomyocytes Cardioprotection Compound 63 (PubChem CID: 75204518)Cyclosporine A (PubChem CID: 5284373)Ischemia MitoParaquat (PubChem CID: 129909777)Mitochondria Permeability transition Reperfusion