Label-Free Interactome Analysis Revealed an Essential Role of CUL3-KEAP1 Complex in Mediating the Ubiquitination and Degradation of PHD2.

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第一作者： Ang,Luo

第一单位： Department of Biochemistry, Molecular Biology and Biophysics , The University of Minnesota at Twin Cities , Minneapolis , Minnesota 55455 , United States.

作者： Ang,Luo ^[1] ; Yue,Chen ^[1]

作者单位： Department of Biochemistry, Molecular Biology and Biophysics , The University of Minnesota at Twin Cities , Minneapolis , Minnesota 55455 , United States. ^[1]

关键词 Cul3 KEAP1 LCMS PHD2/EGLN1 degradation hypoxia ubiquitination

主题词细胞低氧(Cell Hypoxia);CULLIN蛋白质类(Cullin Proteins);基因敲低技术(Gene Knockdown Techniques);人类(Humans);缺氧诱导因子1, α亚基(Hypoxia-Inducible Factor 1, alpha Subunit);多蛋白复合物(Multiprotein Complexes);泛素化(Ubiquitination)

DOI 10.1021/acs.jproteome.9b00513

PMID 31763849

发布时间 2021-04-16

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