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首页> Cancer research> The NOTCH-FOXM1 Axis Plays a Key Role in Mitochondrial Biogenesis in the Induction of Human Stem Cell Memory-like CAR-T Cells.

The NOTCH-FOXM1 Axis Plays a Key Role in Mitochondrial Biogenesis in the Induction of Human Stem Cell Memory-like CAR-T Cells.

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作者： Taisuke,Kondo ^[1] ; Makoto,Ando ^[2] ; Nao,Nagai ^[2] ; Wataru,Tomisato ^[3] ; Tanakorn,Srirat ^[2] ; Binbin,Liu ^[2] ; Setsuko,Mise-Omata ^[2] ; Mari,Ikeda ^[2] ; Shunsuke,Chikuma ^[2] ; Hiroshi,Nishimasu ^[4] ; Osamu,Nureki ^[4] ; Mitsuyo,Ohmura ^[5] ; Noriyo,Hayakawa ^[5] ; Takako,Hishiki ^[5] ; Ryosuke,Uchibori ^[6] ; Keiya,Ozawa ^[6] ; Akihiko,Yoshimura ^[7]

作者单位： Department of Microbiology and Immunology, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan. yoshimura@keio.jp taisuke-kondo@keio.jp. ^[1] Department of Microbiology and Immunology, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan. ^[2] Cell Therapy Research Laboratories, Daiichi Sankyo Co. Ltd., Shinagawa-ku, Tokyo, Japan. ^[3] Department of Biological Science, Graduate School of Science, The University of Tokyo, Bunkyo-ku, Tokyo, Japan. ^[4] Division of Translational Research, Keio University Hospital Clinical and Translational Research Center, Shinjuku-ku, Tokyo, Japan. ^[5] Division of Immuno-Gene and Cell Therapy (Takara Bio), Jichi Medical University, Shimotsuke-shi, Tochigi, Japan. ^[6] Institure of Medical Science, University of Tokyo, Minato-ku, Tokyo, Japan. ^[7]

主题词动物(Animals);细胞分化(Cell Differentiation);共同培养技术(Coculture Techniques);人类(Humans);免疫记忆(Immunologic Memory);免疫疗法, 过继(Immunotherapy, Adoptive);白血病(Leukemia);淋巴细胞活化(Lymphocyte Activation);小鼠(Mice);小鼠, 近交NOD(Mice, Inbred NOD);小鼠, SCID(Mice, SCID);受体, Notch(Receptors, Notch);信号传导(Signal Transduction);干细胞(Stem Cells);间质细胞(Stromal Cells);T淋巴细胞(T-Lymphocytes)

DOI 10.1158/0008-5472.CAN-19-1196

PMID 31767627

发布时间 2020-08-17

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Cancer research

Cancer research

2020年80卷3期

471-483页

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