A structural basis for antibody-mediated neutralization of Nipah virus reveals a site of vulnerability at the fusion glycoprotein apex.

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第一作者： Victoria A,Avanzato

第一单位： Division of Structural Biology, Wellcome Center for Human Genetics, University of Oxford, OX3 7BN Oxford, United Kingdom.

作者： Victoria A,Avanzato ^[1] ; Kasopefoluwa Y,Oguntuyo ^[2] ; Marina,Escalera-Zamudio ^[3] ; Bernardo,Gutierrez ^[4] ; Michael,Golden ^[4] ; Sergei L,Kosakovsky Pond ^[4] ; Rhys,Pryce ^[5] ; Thomas S,Walter ^[1] ; Jeffrey,Seow ^[1] ; Katie J,Doores ^[6] ; Oliver G,Pybus ^[6] ; Vincent J,Munster ^[4] ; Benhur,Lee ^[2] ; Thomas A,Bowden ^[7]

作者单位： Division of Structural Biology, Wellcome Center for Human Genetics, University of Oxford, OX3 7BN Oxford, United Kingdom. ^[1] Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840. ^[2] Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029. ^[3] Department of Zoology, Oxford University, OX1 3PS Oxford, United Kingdom. ^[4] Institute for Genomics and Evolutionary Medicine, Temple University, Philadelphia, PA 19122. ^[5] Department of Infectious Diseases, King's College London, Guy's Hospital, SE1 9RT London, United Kingdom. ^[6] Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029; Benhur.Lee@mssm.edu thomas.bowden@strubi.ox.ac.uk. ^[7] Global Virus Network (GVN) Center of Excellence, Center for Virology, Icahn School of Medicine at Mount Sinai, New York, NY 10029. ^[8] Division of Structural Biology, Wellcome Center for Human Genetics, University of Oxford, OX3 7BN Oxford, United Kingdom; Benhur.Lee@mssm.edu thomas.bowden@strubi.ox.ac.uk. ^[9]

关键词 antibody response glycoprotein henipavirus structure viral fusion