Kindlin-2 suppresses transcription factor GATA4 through interaction with SUV39H1 to attenuate hypertrophy.
第一作者:
Lihua,Qi
第一单位:
Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Human Anatomy, Histology and Embryology, and State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center, Beijing, China.
作者:
主题词
动物(Animals);心脏扩大(Cardiomegaly);细胞支架蛋白质类(Cytoskeletal Proteins);GATA4转录因子(GATA4 Transcription Factor);HEK293细胞(HEK293 Cells);人类(Humans);甲基转移酶类(Methyltransferases);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 基因敲除(Mice, Knockout);模型, 生物学(Models, Biological);肌蛋白质类(Muscle Proteins);肌细胞, 心脏(Myocytes, Cardiac);蛋白质结合(Protein Binding);大鼠, Sprague-Dawley(Rats, Sprague-Dawley);阻遏蛋白质类(Repressor Proteins)
DOI
10.1038/s41419-019-2121-0
PMID
31767831
发布时间
2021-01-10
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