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Loss of fragile X mental retardation protein precedes Lewy pathology in Parkinson's disease.

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第一作者： Yi,Tan

第一单位： Department of Translational Neurodegeneration, German Centre for Neurodegenerative Diseases (DZNE), Munich, Germany.

作者： Yi,Tan ^[1] ; Carmelo,Sgobio ^[2] ; Thomas,Arzberger ^[3] ; Felix,Machleid ^[1] ; Qilin,Tang ^[1] ; Elisabeth,Findeis ^[1] ; Jorg,Tost ^[4] ; Tasnim,Chakroun ^[1] ; Pan,Gao ^[1] ; Mathias,Höllerhage ^[5] ; Kai,Bötzel ^[6] ; Jochen,Herms ^[7] ; Günter,Höglinger ^[8] ; Thomas,Koeglsperger ^[9]

作者单位： Department of Translational Neurodegeneration, German Centre for Neurodegenerative Diseases (DZNE), Munich, Germany. ^[1] Department of Translational Brain Research, German Centre for Neurodegenerative Diseases (DZNE), Munich, Germany. ^[2] Centre of Neuropathology and Prion Research, Ludwig Maximilian University, Munich, Germany.;Department of Psychiatry and Psychotherapy, Ludwig Maximilian University, Munich, Germany. ^[3] Laboratory for Epigenetics and Environment, Centre National de Recherche en Génomique Humaine, CEA-Institut de Biologie François Jacob, Evry, France. ^[4] Department of Translational Neurodegeneration, German Centre for Neurodegenerative Diseases (DZNE), Munich, Germany.;Department of Neurology, Technical University, Munich, Germany. ^[5] Department of Neurology, Ludwig Maximilian University, Munich, Germany. ^[6] Department of Translational Brain Research, German Centre for Neurodegenerative Diseases (DZNE), Munich, Germany.;Centre of Neuropathology and Prion Research, Ludwig Maximilian University, Munich, Germany.;Munich Cluster for Systems Neurology (SyNergy), Munich, Germany. ^[7] Department of Translational Neurodegeneration, German Centre for Neurodegenerative Diseases (DZNE), Munich, Germany.;Department of Neurology, Technical University, Munich, Germany.;Department of Neurology, Hannover Medical School, Hannover, Germany.;Munich Cluster for Systems Neurology (SyNergy), Munich, Germany. ^[8] Department of Translational Neurodegeneration, German Centre for Neurodegenerative Diseases (DZNE), Munich, Germany. thomas.koeglsperger@dzne.de.;Department of Neurology, Ludwig Maximilian University, Munich, Germany. thomas.koeglsperger@dzne.de. ^[9]

关键词 Alpha-Synuclein Fragile X mental retardation protein Fragile X syndrome Lewy body disease N-Type calcium channel Parkinson’s disease