<i>In vivo</i> safety profile of a CSPG4-directed IgE antibody in an immunocompetent rat model.

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第一作者： Iwan P,Williams

第一单位： St John`s Institute of Dermatology, School of Basic and Medical Biosciences, King`s College London, London, UK.

作者： Iwan P,Williams ^[1] ; Silvia,Crescioli ^[1] ; Heng Sheng,Sow ^[1] ; Heather J,Bax ^[2] ; Carl,Hobbs ^[1] ; Kristina M,Ilieva ^[2] ; Elise,French ^[3] ; Giulia,Pellizzari ^[1] ; Vivienne,Cox ^[4] ; Debra H,Josephs ^[1] ; James F,Spicer ^[1] ; Sophia N,Karagiannis ^[2] ; Silvia,Mele ^[5]

作者单位： St John`s Institute of Dermatology, School of Basic and Medical Biosciences, King`s College London, London, UK. ^[1] IGEM Therapeutics Ltd, London BioScience Innovation Centre, London, UK. ^[2] Wolfson Centre for Age-Related Diseases, King's College London, London, UK. ^[3] Breast Cancer Now Research Unit, School of Cancer & Pharmaceutical Sciences, King's College London, Guy's Cancer Centre, London, UK. ^[4] School of Cancer & Pharmaceutical Sciences, King's College London, Bermondsey Wing, Guy's Hospital, Bermondsey Wing, London, UK. ^[5] Department of Medical Oncology, Guy's and St Thomas' NHS Foundation Trust, Guy`s Hospital, London, UK. ^[6] Guy's and St Thomas' NHS Foundation Trust, Department of Oncology, Guy`s Hospital, Bermondsey Wing, London, UK. ^[7]

关键词 CSPG4 IgE allergooncology antibody immunotherapy rat model species cross-reactivity

主题词动物(Animals);抗体依赖细胞细胞毒性(Antibody-Dependent Cell Cytotoxicity);抗原, 肿瘤(Antigens, Neoplasm);细胞系, 肿瘤(Cell Line, Tumor);硫酸软骨素蛋白聚糖类(Chondroitin Sulfate Proteoglycans);交叉反应(Cross Reactions);女(雌)性(Female);人类(Humans);免疫接种, 加强(Immunization, Secondary);免疫活性(Immunocompetence);免疫球蛋白E(Immunoglobulin E);膜蛋白质类(Membrane Proteins);小鼠(Mice);大鼠(Rats);重组融合蛋白质类(Recombinant Fusion Proteins)

DOI 10.1080/19420862.2019.1685349

PMID 31769737

发布时间 2021-05-07

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<i>In vivo</i> safety profile of a CSPG4-directed IgE antibody in an immunocompetent rat model.

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<i>In vivo</i> safety profile of a CSPG4-directed IgE antibody in an immunocompetent rat model.

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