Proteomic and Unbiased Post-Translational Modification Profiling of Amyloid Plaques and Surrounding Tissue in a Transgenic Mouse Model of Alzheimer's Disease.

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作者： Joakim,Bastrup ^[1] ; Kenneth,Kastaniegaard ^[2] ; Ayodeji A,Asuni ^[3] ; Christiane,Volbracht ^[2] ; Allan,Stensballe ^[2]

作者单位： Department of Health Science and Technology, Aalborg University, Aalborg East, Denmark. ^[1] Neuroscience, H. Lundbeck A/S, Valby, Denmark. ^[2] Biogenity, Aalborg, Denmark. ^[3]

关键词 Alzheimer’s disease amyloid plaque mass spectrometry microdissection pyroglutamate

主题词阿尔茨海默病(Alzheimer Disease);酰胺类(Amides);淀粉样β肽类(Amyloid beta-Peptides);动物(Animals);脑(Brain);色谱法, 高压液相(Chromatography, High Pressure Liquid);女(雌)性(Female);谷氨酸盐类(Glutamates);人类(Humans);质谱分析法(Mass Spectrometry);小鼠(Mice);小鼠, 转基因(Mice, Transgenic);氧化还原(Oxidation-Reduction);斑块, 淀粉样(Plaque, Amyloid);蛋白质加工, 转译后(Protein Processing, Post-Translational);蛋白质组学(Proteomics)

DOI 10.3233/JAD-190652

PMID 31771055

发布时间 2021-04-19

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Journal of Alzheimer's disease

2020年73卷1期

393-411页

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Proteomic and Unbiased Post-Translational Modification Profiling of Amyloid Plaques and Surrounding Tissue in a Transgenic Mouse Model of Alzheimer's Disease.

Journal of Alzheimer's disease

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Journal of Alzheimer's disease

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Proteomic and Unbiased Post-Translational Modification Profiling of Amyloid Plaques and Surrounding Tissue in a Transgenic Mouse Model of Alzheimer's Disease.

Journal of Alzheimer's disease

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Journal of Alzheimer's disease

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