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Loss of HIPK2 Protects Neurons from Mitochondrial Toxins by Regulating Parkin Protein Turnover.

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第一作者： Jiasheng,Zhang

第一单位： Department of Pathology, University of California, San Francisco, San Francisco, California 94143.;Pathology Service 113B, VA Medical Center, San Francisco, California 94121.

作者： Jiasheng,Zhang ^[1] ; Yulei,Shang ^[2] ; Sherry,Kamiya ^[2] ; Sarah J,Kotowski ^[3] ; Ken,Nakamura ^[3] ; Eric J,Huang ^[4]

作者单位： Department of Pathology, University of California, San Francisco, San Francisco, California 94143.;Pathology Service 113B, VA Medical Center, San Francisco, California 94121. ^[1] Department of Pathology, University of California, San Francisco, San Francisco, California 94143. ^[2] Department of Neurology, University of California, San Francisco, San Francisco, California 94122, and.;Gladstone Institute of Neurological Disease, San Francisco, California 94158. ^[3] Department of Pathology, University of California, San Francisco, San Francisco, California 94143, eric.huang2@ucsf.edu.;Pathology Service 113B, VA Medical Center, San Francisco, California 94121. ^[4]

关键词 HIPK2 PGC-1 Parkin mitochondria mitophagy proteasome

医学主题词动物(Animals);女(雌)性(Female);成纤维细胞(Fibroblasts);基因表达调控(Gene Expression Regulation);男(雄)性(Male);膜电位, 线粒体(Membrane Potential, Mitochondrial);小鼠(Mice);小鼠, 129系(Mice, 129 Strain);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 基因敲除(Mice, Knockout);线粒体(Mitochondria);神经元(Neurons);神经保护药(Neuroprotective Agents);神经毒素类(Neurotoxins);蛋白激酶类(Protein Kinases);泛素蛋白连接酶类(Ubiquitin-Protein Ligases)

DOI 10.1523/JNEUROSCI.2017-19.2019

PMID 31776210

发布时间 2024-09-22

基金项目

R01 NS091902/NS/NINDS NIH HHS/United States S10 OD021822/OD/NIH HHS/United States R01 NS098516/NS/NINDS NIH HHS/United States P30 DK063720/DK/NIDDK NIH HHS/United States I01 BX001108/BX/BLRD VA/United States

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