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A Synergistic Anticancer FAK and HDAC Inhibitor Combination Discovered by a Novel Chemical-Genetic High-Content Phenotypic Screen.

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第一作者： John C,Dawson

第一单位： Cancer Research UK Edinburgh Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom.

作者： John C,Dawson ^[1] ; Bryan,Serrels ^[1] ; Adam,Byron ^[1] ; Morwenna T,Muir ^[1] ; Ashraff,Makda ^[1] ; Amaya,García-Muñoz ^[2] ; Alex,von Kriegsheim ^[3] ; Daniel,Lietha ^[4] ; Neil O,Carragher ^[5] ; Margaret C,Frame ^[5]

作者单位： Cancer Research UK Edinburgh Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom. ^[1] Systems Biology Ireland, University College Dublin, Dublin, Ireland. ^[2] Cancer Research UK Edinburgh Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom.;Systems Biology Ireland, University College Dublin, Dublin, Ireland. ^[3] Cell Signaling and Adhesion Group, Structural Biology Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain. ^[4] Cancer Research UK Edinburgh Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom. m.frame@ed.ac.uk n.carragher@ed.ac.uk. ^[5]