Human iPSC-derived astrocytes from ALS patients with mutated C9ORF72 show increased oxidative stress and neurotoxicity.

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第一作者： Anastasya,Birger

第一单位： The Sidney and Judy Swartz Embryonic Stem Cell Research Center of The Goldyne Savad Institute of Gene Therapy & The Department of Obstetrics & Gynecology, Hadassah University Medical Center, Jerusalem 91120, Israel; Department of Developmental Biology and Cancer Research, Institute of Medical Research Israel-Canada (IMRIC), Faculty of Medicine, The Hebrew University, P.O. Box 12272, 91120 Jerusalem, Israel.

作者： Anastasya,Birger ^[1] ; Israel,Ben-Dor ^[2] ; Miri,Ottolenghi ^[2] ; Tikva,Turetsky ^[2] ; Yaniv,Gil ^[2] ; Sahar,Sweetat ^[3] ; Liat,Perez ^[3] ; Vitali,Belzer ^[3] ; Natania,Casden ^[3] ; Debora,Steiner ^[2] ; Michal,Izrael ^[4] ; Eithan,Galun ^[5] ; Eva,Feldman ^[6] ; Oded,Behar ^[7] ; Benjamin,Reubinoff ^[8]

作者单位： The Sidney and Judy Swartz Embryonic Stem Cell Research Center of The Goldyne Savad Institute of Gene Therapy & The Department of Obstetrics & Gynecology, Hadassah University Medical Center, Jerusalem 91120, Israel; Department of Developmental Biology and Cancer Research, Institute of Medical Research Israel-Canada (IMRIC), Faculty of Medicine, The Hebrew University, P.O. Box 12272, 91120 Jerusalem, Israel. ^[1] The Sidney and Judy Swartz Embryonic Stem Cell Research Center of The Goldyne Savad Institute of Gene Therapy & The Department of Obstetrics & Gynecology, Hadassah University Medical Center, Jerusalem 91120, Israel. ^[2] Department of Developmental Biology and Cancer Research, Institute of Medical Research Israel-Canada (IMRIC), Faculty of Medicine, The Hebrew University, P.O. Box 12272, 91120 Jerusalem, Israel. ^[3] Kadimastem Ltd., Sapir 7, Weizmann Science Park, Nes-Ziona, Israel. ^[4] The Goldyne Savad Institute of Gene Therapy, Hadassah University Medical Center, Jerusalem 91120, Israel. ^[5] Department of Neurology, University of Michigan, Ann Arbor, MI, USA. ^[6] Department of Developmental Biology and Cancer Research, Institute of Medical Research Israel-Canada (IMRIC), Faculty of Medicine, The Hebrew University, P.O. Box 12272, 91120 Jerusalem, Israel. Electronic address: oded.behar@mail.huji.ac.il. ^[7] The Sidney and Judy Swartz Embryonic Stem Cell Research Center of The Goldyne Savad Institute of Gene Therapy & The Department of Obstetrics & Gynecology, Hadassah University Medical Center, Jerusalem 91120, Israel. Electronic address: BenR@hadassah.org.il. ^[8]

关键词 Amyotrophic lateral sclerosis Astrocytes Neurotoxicity Oxidative stress Senescence iPSC

主题词肌萎缩侧索硬化(Amyotrophic Lateral Sclerosis);动物(Animals);星形细胞(Astrocytes);细胞, 培养的(Cells, Cultured);大脑皮质(Cerebral Cortex);疾病模型, 动物(Disease Models, Animal);基因表达谱(Gene Expression Profiling);谷氨酸(Glutamic Acid);人类(Humans);诱导多能干细胞(Induced Pluripotent Stem Cells);小鼠(Mice);运动神经元(Motor Neurons);突变(Mutation);氧化性应激(Oxidative Stress);蛋白质组学(Proteomics);活性氧(Reactive Oxygen Species)

DOI 10.1016/j.ebiom.2019.11.026

PMID 31787569

发布时间 2024-07-23

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Human iPSC-derived astrocytes from ALS patients with mutated C9ORF72 show increased oxidative stress and neurotoxicity.

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Human iPSC-derived astrocytes from ALS patients with mutated C9ORF72 show increased oxidative stress and neurotoxicity.

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