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Accumulation of kynurenine elevates oxidative stress and alters microRNA profile in human bone marrow stromal cells.

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第一作者： Sherwood,Dalton

第一单位： Department of Orthopedics, Augusta University, Augusta, GA, United States of America.

作者： Sherwood,Dalton ^[1] ; Kathryn,Smith ^[1] ; Kanwar,Singh ^[1] ; Helen,Kaiser ^[2] ; Ravindra,Kolhe ^[3] ; Ashis K,Mondal ^[3] ; Andrew,Khayrullin ^[2] ; Carlos M,Isales ^[4] ; Mark W,Hamrick ^[5] ; William D,Hill ^[6] ; Sadanand,Fulzele ^[7]

作者单位： Department of Orthopedics, Augusta University, Augusta, GA, United States of America. ^[1] Department of Cell biology and Anatomy, Augusta University, Augusta, GA, United States of America. ^[2] Departments of Pathology, Augusta University, Augusta, GA 30912, United States of America. ^[3] Department of Orthopedics, Augusta University, Augusta, GA, United States of America; Department of Medicine, Augusta University, Augusta, GA, United States of America; Institute of Healthy Aging, Augusta University, Augusta, GA, United States of America. ^[4] Department of Orthopedics, Augusta University, Augusta, GA, United States of America; Department of Cell biology and Anatomy, Augusta University, Augusta, GA, United States of America; Institute of Healthy Aging, Augusta University, Augusta, GA, United States of America. ^[5] Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC 29403, United States of America; Ralph H Johnson Veterans Affairs Medical Center, Charleston, SC, 29403, United States of America. ^[6] Department of Orthopedics, Augusta University, Augusta, GA, United States of America; Department of Cell biology and Anatomy, Augusta University, Augusta, GA, United States of America; Institute of Healthy Aging, Augusta University, Augusta, GA, United States of America. Electronic address: sfulzele@augusta.edu. ^[7]

关键词 Human bone marrow stromal cells Kynurenine Oxidative stress microRNAs