Interleukin-22 orchestrates a pathological endoplasmic reticulum stress response transcriptional programme in colonic epithelial cells.-论文-万方医学网

作者： Nick,Powell ^[1] ; Eirini,Pantazi ^[2] ; Polychronis,Pavlidis ^[3] ; Anastasia,Tsakmaki ^[4] ; Katherine,Li ^[4] ; Feifei,Yang ^[5] ; Aimee,Parker ^[6] ; Carmen,Pin ^[6] ; Domenico,Cozzetto ^[7] ; Danielle,Minns ^[7] ; Emilie,Stolarczyk ^[2] ; Svetlana,Saveljeva ^[8] ; Rami,Mohamed ^[4] ; Paul,Lavender ^[4] ; Behdad,Afzali ^[9] ; Jonathan,Digby-Bell ^[4] ; Tsui,Tjir-Li ^[4] ; Arthur,Kaser ^[4] ; Joshua,Friedman ^[4] ; Thomas T,MacDonald ^[4] ; Gavin A,Bewick ^[9] ; Graham M,Lord ^[6]

作者单位： School of Immunology and Microbial Sciences, King's College London, London, UK npowell@ic.ac.uk graham.lord@kcl.ac.uk. ^[1] National Institute for Health Research Biomedical Research Centre at Guy's and St Thomas' NHS Foundation Trust and King's College London, London, UK. ^[2] Division of Digestive Diseases, Faculty of Medicine, Imperial College London, London, UK. ^[3] School of Immunology and Microbial Sciences, King's College London, London, UK. ^[4] Diabetes Research Group, School of Life Course Sciences, Faculty of Life Sciences and Medicine, Kings College London, London, UK. ^[5] Janssen Research & Development, Spring House, Pennsylvania, USA. ^[6] Quadram Institute Bioscience, Norwich, Norfolk, UK. ^[7] Department of Translational Bioinformatics, National Institute for Health Research Biomedical Research Centre at Guy's and St Thomas' NHS Foundation Trust and King's College London, London, UK. ^[8] Division of Gastroenterology and Hepatology, Department of Medicine, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK. ^[9] Centre for Immunology and Infectious Disease, Bart's & the London School of Medicine and Dentistry, Blizard Institute of Cell and Molecular Science, London, UK. ^[10] Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK. ^[11]

主题词动物(Animals);抗菌药(Anti-Bacterial Agents);细胞凋亡(Apoptosis);细胞存活(Cell Survival);慢性病(Chronic Disease);结肠炎(Colitis);结肠(Colon);Crohn病(Crohn Disease);疾病模型, 动物(Disease Models, Animal);上皮细胞(Epithelial Cells);胃肠病用药(Gastrointestinal Agents);人类(Humans);白细胞介素17(Interleukin-17);白细胞介素23(Interleukin-23);白细胞介素类(Interleukins);肠黏膜(Intestinal Mucosa);小鼠(Mice);类器官(Organoids);丁酸苯酯类(Phenylbutyrates);重组蛋白质类(Recombinant Proteins);转录, 遗传(Transcription, Genetic);衣霉素(Tunicamycin);非折叠蛋白质应答(Unfolded Protein Response)

DOI 10.1136/gutjnl-2019-318483

PMID 31792136

发布时间 2023-12-13

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Interleukin-22 orchestrates a pathological endoplasmic reticulum stress response transcriptional programme in colonic epithelial cells.

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Interleukin-22 orchestrates a pathological endoplasmic reticulum stress response transcriptional programme in colonic epithelial cells.

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