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Blood-brain barrier dysfunction in aging induces hyperactivation of TGFβ signaling and chronic yet reversible neural dysfunction.

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第一作者: Vladimir V,Senatorov
第一单位: Helen Wills Neuroscience Institute and Berkeley Stem Cell Center, University of California, Berkeley, Berkeley, CA 94720, USA.;Department of Integrative Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
作者单位: Helen Wills Neuroscience Institute and Berkeley Stem Cell Center, University of California, Berkeley, Berkeley, CA 94720, USA.;Department of Integrative Biology, University of California, Berkeley, Berkeley, CA 94720, USA. [1] Departments of Physiology and Cell Biology, Cognitive and Brain Sciences, Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel. [2] Department of Integrative Biology, University of California, Berkeley, Berkeley, CA 94720, USA.;Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA. [3] Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA. [4] Department of Bioengineering, University of California, Berkeley, Berkeley, CA 94720, USA. [5] Department of Integrative Biology, University of California, Berkeley, Berkeley, CA 94720, USA. [6] School of Public Health, University of California, Berkeley, Berkeley, CA 94720, USA. [7] Section for Translational Epilepsy Research, Department of Neuropathology, University of Bonn Medical Center, Bonn, Germany. [8] Innovation Pathways, Palo Alto, CA 94301, USA. [9] Department of Neurology, School of Medicine, University of California, Davis, Sacramento, CA 95817, USA. [10] Glenn Center for Aging Research, Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA. [11] Departments of Physiology and Cell Biology, Cognitive and Brain Sciences, Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel.;Department of Medical Neuroscience and Brain Repair Center, Dalhousie University, Halifax, NS B3H4R2, Canada. [12] Helen Wills Neuroscience Institute and Berkeley Stem Cell Center, University of California, Berkeley, Berkeley, CA 94720, USA. danielak@berkeley.edu.;Department of Integrative Biology, University of California, Berkeley, Berkeley, CA 94720, USA.;Canadian Institute for Advanced Research, Toronto, ON M5G1M1, Canada. [13]
DOI 10.1126/scitranslmed.aaw8283
PMID 31801886
发布时间 2024-12-05
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