IL-13 and IL-4, but not IL-5 nor IL-17A, induce hyperresponsiveness in isolated human small airways.

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作者： Martijn L,Manson ^[1] ; Jesper,Säfholm ^[2] ; Anna,James ^[2] ; Anna-Karin,Johnsson ^[2] ; Per,Bergman ^[3] ; Mamdoh,Al-Ameri ^[3] ; Ann-Charlotte,Orre ^[4] ; Carina,Kärrman-Mårdh ^[5] ; Sven-Erik,Dahlén ^[2] ; Mikael,Adner ^[6]

作者单位： Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden; Bioscience, Respiratory, Inflammation and Autoimmunity (RIA), IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden. ^[1] Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden. ^[2] Department of Molecular Medicine and Surgery (MMK), Karolinska Institutet, Stockholm, Sweden; Department of Cardiothoracic Surgery and Anesthesiology, Karolinska University Hospital, Stockholm, Sweden. ^[3] Department of Molecular Medicine and Surgery (MMK), Karolinska Institutet, Stockholm, Sweden. ^[4] Bioscience, Respiratory, Inflammation and Autoimmunity (RIA), IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden. ^[5] Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden. Electronic address: mikael.adner@ki.se. ^[6]

关键词 Airway smooth muscle IL-4Rα STAT6 airway hyperresponsiveness bronchoconstriction explanted human tissue model bronchoconstrictor agents calcium signaling dupilumab glucocorticoid