Biomarker-guided antibiotic stewardship in suspected ventilator-associated pneumonia (VAPrapid2): a randomised controlled trial and process evaluation.
作者:
Thomas P,Hellyer [1]
;
Daniel F,McAuley [2]
;
Timothy S,Walsh [3]
;
Niall,Anderson [4]
;
Andrew,Conway Morris [5]
;
Suveer,Singh [6]
;
Paul,Dark [7]
;
Alistair I,Roy [8]
;
Gavin D,Perkins [9]
;
Ronan,McMullan [10]
;
Lydia M,Emerson [10]
;
Bronagh,Blackwood [10]
;
Stephen E,Wright [11]
;
Kallirroi,Kefala [12]
;
Cecilia M,O'Kane [10]
;
Simon V,Baudouin [13]
;
Ross L,Paterson [14]
;
Anthony J,Rostron [15]
;
Ashley,Agus [16]
;
Jonathan,Bannard-Smith [17]
;
Nicole M,Robin [18]
;
Ingeborg D,Welters [19]
;
Christopher,Bassford [20]
;
Bryan,Yates [21]
;
Craig,Spencer [22]
;
Shondipon K,Laha [22]
;
Jonathan,Hulme [23]
;
Stephen,Bonner [24]
;
Vanessa,Linnett [25]
;
Julian,Sonksen [26]
;
Tina,Van Den Broeck [27]
;
Gert,Boschman [27]
;
Dw James,Keenan [27]
;
Jonathan,Scott [1]
;
A Joy,Allen [28]
;
Glenn,Phair [16]
;
Jennie,Parker [29]
;
Susan A,Bowett [29]
;
A John,Simpson [30]
作者单位:
Translational and Clinical Research Institute, Newcastle University, Newcastle, UK.
[1]
The Wellcome-Wolfson Centre for Experimental Medicine, Queen's University Belfast, Belfast, UK; Regional Intensive Care Unit, The Royal Hospitals, Belfast, UK.
[2]
Anaesthesia, Critical Care and Pain Medicine, University of Edinburgh, Queen's Medical Research Institute, Edinburgh, UK; Intensive Care Unit, Royal Infirmary of Edinburgh, Edinburgh, UK.
[3]
Usher Institute, University of Edinburgh, Edinburgh, UK.
[4]
Division of Anaesthesia, Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.
[5]
Department of Cancer and Surgery, Imperial College London, London, UK.
[6]
Division of Infection Immunity and Respiratory Medicine, Manchester National Institute for Health Research Biomedical Research Centre, University of Manchester, Manchester, UK.
[7]
Integrated Critical Care Unit, Sunderland Royal Hospital, City Hospitals Sunderland NHS Foundation Trust, Sunderland, UK.
[8]
Warwick Medical School, University of Warwick, Coventry, UK; Intensive Care Unit, Heartlands Hospital, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
[9]
The Wellcome-Wolfson Centre for Experimental Medicine, Queen's University Belfast, Belfast, UK.
[10]
Integrated Critical Care Unit, Freeman Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle, UK.
[11]
Intensive Care Unit, Royal Infirmary of Edinburgh, Edinburgh, UK.
[12]
Intensive Care Unit, Royal Victoria Infirmary, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle, UK.
[13]
Intensive Care Unit, Western General Hospital, Edinburgh, UK.
[14]
Translational and Clinical Research Institute, Newcastle University, Newcastle, UK; Integrated Critical Care Unit, Sunderland Royal Hospital, City Hospitals Sunderland NHS Foundation Trust, Sunderland, UK.
[15]
Northern Ireland Clinical Trials Unit, The Royal Hospitals, Belfast, UK.
[16]
Intensive Care Unit, Manchester Royal Infirmary, Manchester University NHS Foundation Trust, Manchester, UK.
[17]
Intensive Care Unit, Countess of Chester NHS Foundation Trust, Chester, UK.
[18]
Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK.
[19]
Intensive Care Unit, University Hospital Coventry, University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK.
[20]
Intensive Care Unit, Northumbria Specialist Emergency Care Hospital, Cramlington, UK.
[21]
Intensive Care Unit, Preston Royal Hospital, Lancashire Teaching Hospitals NHS Foundation Trust, Preston, UK.
[22]
Intensive Care Unit, Sandwell General Hospital, Sandwell and West Birmingham Hospitals NHS Trust, West Bromwich, UK.
[23]
Intensive Care Unit, James Cook University Hospital, South Tees Hospitals NHS Foundation Trust, Middlesbrough, UK.
[24]
Intensive Care Unit, Queen Elizabeth Hospital, Gateshead NHS Foundation Trust, Gateshead, UK.
[25]
Intensive Care Unit, Russells Hall Hospital, Dudley Group NHS Foundation Trust, Dudley, UK.
[26]
Becton Dickinson Biosciences Europe, Erembodegem, Belgium.
[27]
National Institute for Health Research Newcastle In Vitro Diagnostics Cooperative, Newcastle University, Newcastle, UK.
[28]
Newcastle Clinical Trials Unit, Newcastle University, Newcastle, UK.
[29]
Translational and Clinical Research Institute, Newcastle University, Newcastle, UK; National Institute for Health Research Newcastle In Vitro Diagnostics Cooperative, Newcastle University, Newcastle, UK. Electronic address: j.simpson@ncl.ac.uk.
[30]
主题词
抗菌药(Anti-Bacterial Agents);支气管肺泡灌洗(Bronchoalveolar Lavage);支气管肺泡灌洗液(Bronchoalveolar Lavage Fluid);女(雌)性(Female);人类(Humans);男(雄)性(Male);中年人(Middle Aged);肺炎, 呼吸机相关性(Pneumonia, Ventilator-Associated);公费医疗(State Medicine)
DOI
10.1016/S2213-2600(19)30367-4
PMID
31810865
发布时间
2024-02-07
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The Lancet. Respiratory medicine
The Lancet. Respiratory medicine
2020年8卷2期
182-191页
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