Mutations that improve efficiency of a weak-link enzyme are rare compared to adaptive mutations elsewhere in the genome.

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第一作者： Andrew B,Morgenthaler

第一单位： Department of Molecular, Cellular, and Developmental Biology, University of Colorado Boulder, Boulder, United States.

作者： Andrew B,Morgenthaler ^[1] ; Wallis R,Kinney ^[2] ; Christopher C,Ebmeier ^[1] ; Corinne M,Walsh ^[2] ; Daniel J,Snyder ^[1] ; Vaughn S,Cooper ^[2] ; William M,Old ^[3] ; Shelley D,Copley ^[4]

作者单位： Department of Molecular, Cellular, and Developmental Biology, University of Colorado Boulder, Boulder, United States. ^[1] Cooperative Institute for Research in Environmental Sciences, University of Colorado Boulder, Boulder, United States. ^[2] Department of Ecology and Evolutionary Biology, University of Colorado Boulder, Boulder, United States. ^[3] Center for Evolutionary Biology and Medicine, University of Pittsburgh, Pittsburgh, United States. ^[4]

关键词 E. coli ProA amplification and divergence evolution evolutionary biology genetics genomics promiscuity

主题词适应, 生物学(Adaptation, Biological);酶类(Enzymes);大肠杆菌(Escherichia coli);遗传适合度(Genetic Fitness);基因组, 细菌(Genome, Bacterial);代谢网络和途径(Metabolic Networks and Pathways);突变(Mutation)

DOI 10.7554/eLife.53535

PMID 31815667

发布时间 2020-05-26

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准确一般字义偏差语意偏离译文作用小提交