Insight into the mechanism of allosteric activation of PI3Kα by oncoprotein K-Ras4B.

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作者： Xinyi,Li ^[1] ; Jinyuan,Dai ^[2] ; Duan,Ni ^[1] ; Xinheng,He ^[1] ; Hao,Zhang ^[1] ; Jian,Zhang ^[1] ; Qiang,Fu ^[3] ; Yaqin,Liu ^[4] ; Shaoyong,Lu ^[5]

作者单位： Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University, School of Medicine, Shanghai 200025, China. ^[1] Chemical Engineering and Technology, School of Chemical Engineering, East China University of Science and Technology, Shanghai 201424, China. ^[2] Department of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai 200080, China. Electronic address: johson.f@163.com. ^[3] Medicinal Bioinformatics Center, Shanghai Jiao Tong University, School of Medicine, Shanghai 200025, China. Electronic address: liuyaqin7811@126.com. ^[4] Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University, School of Medicine, Shanghai 200025, China; Medicinal Bioinformatics Center, Shanghai Jiao Tong University, School of Medicine, Shanghai 200025, China. Electronic address: lushaoyong@yeah.net. ^[5]

关键词 Allosteric communication Allosteric effects Allosteric regulation Molecular dynamics simulations PI3K Protein-protein interactions Ras