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Non-Syndromic Cleft Lip with or without Cleft Palate: Genome-Wide Association Study in Europeans Identifies a Suggestive Risk Locus at 16p12.1 and Supports <i>SH3PXD2A</i> as a Clefting Susceptibility Gene.

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作者单位: Department for Health Evidence, Radboud Institute for Health Sciences, Radboud university medical center, 6500 HB Nijmegen, The Netherlands. [1] Institute of Human Genetics, University of Bonn, 53127 Bonn, Germany. [2] Department of Dentistry, Radboud Institute for Health Sciences, Section of Orthodontics and Craniofacial Biology, Radboud university medical center, 6500 HB Nijmegen, The Netherlands. [3] Department of Oral and Maxillofacial Surgery, Radboud university medical center, 6500 HB Nijmegen, The Netherlands. [4] Orthodontic Department, College of Dentistry, Thamar University, Thamar, Yemen. [5] Tecnologico de Monterrey, School of Medicine, and Universidad Autonoma de Nuevo Leon, Centro de Investigación y Desarrollo en Ciencias de la Salud, Monterrey 64460, Mexico. [6] Department for Health Evidence, Radboud Institute for Health Sciences, Radboud university medical center, 6500 HB Nijmegen, The Netherlands.;Department of Urology, Radboud Institute for Health Sciences, Radboud university medical center, 6500 HB Nijmegen, The Netherlands. [7] Department of Human Genetics, KU Leuven, 3000 Leuven, Belgium. [8] Department of Human Genetics, and Donders Institute for Brain, Cognition and Behaviour, Radboud university medical center, 6500 HB Nijmgen, The Netherlands.;Department of Clinical Genetics, and GROW School for Oncology and Developmental Biology, Maastricht University Medical Center, 6202 AZ Maastricht, The Netherlands. [9] Center for Human Genetics, University Hospitals Leuven, KU Leuven, 3000 Leuven, Belgium. [10] Department of Imaging and Pathology, KU Leuven, 3000 Leuven, Belgium.;Oral and Maxillofacial Surgery, University Hospitals Leuven, 3000 Leuven, Belgium. [11] Department of Neurosciences, Experimental Otorhinolaryngology, KU Leuven, 3000 Leuven, Belgium. [12] Institute of Medical Biometry, Informatics and Epidemiology, University of Bonn, 53127 Bonn, Germany. [13] Department of Human Genetics, KU Leuven, 3000 Leuven, Belgium.;Department of Human Genetics, and Donders Institute for Brain, Cognition and Behaviour, Radboud university medical center, 6500 HB Nijmgen, The Netherlands.;Orthodontics, University Hospitals KU Leuven, 3000 Leuven, Belgium. [14]
DOI 10.3390/genes10121023
PMID 31817908
发布时间 2024-12-07
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